A wide range of sleep dysfunction complicates Parkinson's disease during its course from prodromal to palliative stage. It is now increasingly acknowledged that sleep disturbances are thus integral to the disease and pose a significant burden impacting on quality of life of patients. Sleep fragmentation, restless legs syndrome, nocturia, and nocturnal pain are regarded as one of the main components of night-time sleep dysfunction with possible secondary impact on cognition and well-being. The role of dopaminergic therapies, particularly using a continuous drug delivery strategy in managing some of these sleep issues, have been reported but the overall concept remains unclear. This review provides an overview of several aspects of night-time sleep dysfunction in Parkinson's disease and describes all available published open-label and blinded studies that investigated the use of rotigotine transdermal patch targeting sleep. Blinded studies have suggested beneficial effects of rotigotine transdermal patch on maintenance insomnia and restless legs syndrome in Parkinson's disease patients. Open-label studies support these observations and also suggest beneficial effects on nocturia and nocturnal pain.

中文翻译：

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罗替戈汀的透皮贴剂和帕金森氏病的睡眠：我们现在在哪里？

从前驱期到姑息期，广泛的睡眠功能障碍会使帕金森氏病复杂化。现在，人们越来越认识到，睡眠障碍是该疾病不可或缺的一部分，并构成了影响患者生活质量的重大负担。睡眠支离破碎，腿不安宁综合症，夜尿症和夜间疼痛被认为是夜间睡眠功能障碍的主要因素之一，可能对认知和幸福感产生继发性影响。据报道，多巴胺能疗法的作用，特别是在治疗某些睡眠问题中使用连续药物输送策略的作用，但总体概念尚不清楚。这篇综述概述了帕金森氏症夜间睡眠功能障碍的几个方面 并描述了所有可用的公开标签和盲法研究，这些研究调查了使用罗替戈汀透皮贴剂靶向睡眠的情况。盲目研究表明，罗替戈汀透皮贴剂对帕金森氏病患者的失眠和腿部不安综合症具有有益的作用。开放标签研究支持了这些观察结果，并且还提出了对夜尿和夜间疼痛的有益作用。