Immunometabolism at the interface between macrophages and pathogens.,Nature Reviews Immunology

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Immunometabolism at the interface between macrophages and pathogens.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-05-01 , DOI: 10.1038/s41577-019-0124-9
David G Russell ₁ , Lu Huang ₁ , Brian C VanderVen ₁

Affiliation

It is generally regarded that the progression of an infection within host macrophages is the consequence of a failed immune response. However, recent appreciation of macrophage heterogeneity, with respect to both development and metabolism, indicates that the reality is more complex. Different lineages of tissue-resident macrophages respond divergently to microbial, environmental and immunological stimuli. The emerging picture that the developmental origin of macrophages determines their responses to immune stimulation and to infection stresses the importance of in vivo infection models. Recent investigations into the metabolism of infecting microorganisms and host macrophages indicate that their metabolic interface can be a major determinant of pathogen growth or containment. This Review focuses on the integration of data from existing studies, the identification of challenges in generating and interpreting data from ongoing studies and a discussion of the technologies and tools that are required to best address future questions in the field.

中文翻译：

巨噬细胞和病原体之间界面的免疫代谢。

人们普遍认为宿主巨噬细胞内感染的进展是免疫反应失败的结果。然而，最近对巨噬细胞在发育和代谢方面的异质性的认识表明，现实更为复杂。组织驻留巨噬细胞的不同谱系对微生物、环境和免疫刺激有不同的反应。巨噬细胞的发育起源决定了它们对免疫刺激和感染的反应的新观点强调了体内感染模型的重要性。最近对感染微生物和宿主巨噬细胞代谢的研究表明，它们的代谢界面可能是病原体生长或遏制的主要决定因素。本综述的重点是整合现有研究的数据，确定生成和解释正在进行的研究的数据的挑战，以及讨论最好地解决该领域未来问题所需的技术和工具。

更新日期：2019-01-24

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