Myrciaria cauliflora (jaboticaba) is an edible fruit common in Brazil that has been used for treating respiratory diseases, including chronic tonsillitis and asthma. This study explores the distribution of an anti-inflammatory depside, jaboticabin, in different parts of the jaboticaba plant as well as major polyphenols from the wood of jaboticaba, some with biological activity similar to jaboticabin. The peel of the fruit was found to be the major source of jaboticabin. This is the first phytochemical study of the wood of M. cauliflora. The antioxidant-activity-guided fractionation strategy successfully identified 3,3′-dimethylellagic acid-4-O-sulfate from jaboticaba wood. This ellagic acid derivative, in a manner similar to jaboticabin, showed antiradical activity and inhibited the production of the chemokine interleukin-8 after treating the human small airway epithelial cells with cigarette smoke extract. The human intestinal Caco-2 cell studies demonstrated the jaboticabin transport in vitro. The polyphenols, jaboticabin and 3,3′-dimethyellagic acid-4-O-sulfate, from jaboticaba were both found to exhibit anti-inflammatory activities, thus suggesting the potential use of these compounds or even the fruits themselves for chronic obstructive pulmonary disease.

中文翻译：

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Jaboticaba（Myrciaria cauliflora）的Jaboticabin及其相关多酚对慢性阻塞性肺疾病具有抗炎活性

菜豆Myrciaria cauliflora（jaboticaba）是巴西常见的可食用水果，已用于治疗呼吸系统疾病，包括慢性扁桃体炎和哮喘。这项研究探索了消炎药jaboticabin在jaboticaba植物的不同部位以及来自jaboticaba木材中的主要多酚的分布，其中一些具有与jaboticabin相似的生物活性。发现果皮是茉莉花素的主要来源。这是花椰菜木材的首次植物化学研究。抗氧化剂活性指导的分馏策略成功鉴定了3,3'-二甲基鞣花酸-4- O-来自非洲辣椒的硫酸盐。该鞣花酸衍生物以类似于茉莉花红素的方式表现出抗自由基活性，并在用香烟烟雾提取物处理人的小气道上皮细胞后抑制了趋化因子白细胞介素8的产生。人类肠道Caco-2细胞研究证明了jaboticabin在体外的转运。发现来自非洲藜麦的多酚，茉莉花香素和3,3'-二甲基美拉基酸-4- O-硫酸盐均具有抗炎活性，因此表明这些化合物或什至是水果本身也可用于慢性阻塞性肺疾病。