We report here an injectable, self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic wound regeneration. The hydrogel was prepared by coordinative cross-linking of multi-arm thiolated polyethylene glycol (SH-PEG) with silver nitrate (AgNO3). Due to the dynamic nature of Ag-S coordination bond and bacteria-killing activity of Ag+, the resultant coordinative hydrogel featured self-healing, injectable and antibacterial properties. In this study, we synchronously loaded an angiogenic drug, desferrioxamine (DFO), in the coordinative hydrogel during cross-linking. We finally obtained a multifunctional hydrogel that is manageable, resistant to mechanical irritation, antibacterial and angiogenic in vitro. Our in vivo studies further demonstrated that the injectable self-healing hydrogel could efficiently repair diabetic skin wounds with low bacteria-infection and enhance angiogenic activity. In short, besides diabetic skin wound repair, such dynamic multifunctional hydrogel scaffolds would show great promise in the regeneration of different types of exposed wounds, in particular, in situations with disturbed physiological functions, high risk of bacterial infections, and external mechanical irritation.

我们在这里报告了一种可注射的，具有自我修复作用的水凝胶，具有抗菌和血管生成特性，可用于糖尿病伤口的再生。通过多臂硫醇化聚乙二醇（SH-PEG）与硝酸银（AgNO3）的配位交联制备水凝胶。由于Ag-S配位键的动态性质和Ag +的杀菌作用，所得配位水凝胶具有自我修复，可注射和抗菌的特性。在这项研究中，我们在交联过程中在配位水凝胶中同步加载了一种血管生成药物去铁胺（DFO）。我们最终获得了一种多功能水凝胶，该水凝胶易于处理，在体外对机械刺激，抗菌和血管生成具有抵抗力。我们的体内研究进一步表明，可注射的自愈水凝胶可以有效地修复低细菌感染的糖尿病皮肤伤口并增强血管生成活性。简而言之，除了糖尿病皮肤伤口修复之外，这种动态多功能水凝胶支架在不同类型的暴露伤口的再生中，特别是在生理功能受到干扰，细菌感染的风险高以及外部机械刺激的情况下，将显示出巨大的希望。