Abstract Since the mussel-inspired multifunctional coating was introduced in 2007, it has been utilized to modify membranes for a wide range of applications including ultrafiltration and nanofiltration. In this work, the effects of substrate pore size and coating conditions on the separation performance of organic solvent nanofiltration (OSN) membranes were investigated. By using sulfonated polyphenylenesulfone (sPPSU) as the substrate material and polyethyleneimine and pyrocatechol as the coating materials, OSN membranes can be fabricated if the pores of the sPPSU substrates are less than 12 nm in diameter (determined by the solute transport method). The coated membranes show rejections greater than 93% towards molecules with molecular weights larger than 645 g/mol and a permeance of 11.9 L m−2 h−1 bar−1 in ethanol. The addition of epichlorohydrin in the coating solution can significantly enhance membrane rejections to small molecules. The fabricated membranes demonstrate good stability in 7-day tetracycline filtration tests. The 2-pass rejection can reach 96.2% to tetracycline for tetracycline/isopropanol solutions. The newly developed one-step facile coating method has great potential to fabricate membranes for OSN applications in the pharmaceutical industry.

中文翻译：

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通过简便的仿生一步改性制备有机溶剂纳滤膜

摘要 自 2007 年推出受贻贝启发的多功能涂层以来，它已被用于对膜进行改性，以用于包括超滤和纳滤在内的广泛应用。在这项工作中，研究了基材孔径和涂层条件对有机溶剂纳滤 (OSN) 膜分离性能的影响。通过使用磺化聚苯砜 (sPPSU) 作为基材，聚乙烯亚胺和邻苯二酚作为涂层材料，如果 sPPSU 基材的孔直径小于 12 nm（由溶质传输方法确定），则可以制造 OSN 膜。涂层膜对分子量大于 645 g/mol 且在乙醇中渗透率为 11.9 L m-2 h-1 bar-1 的分子显示出大于 93% 的截留率。在涂层溶液中添加环氧氯丙烷可以显着提高膜对小分子的截留率。制成的膜在 7 天四环素过滤测试中表现出良好的稳定性。对于四环素/异丙醇溶液，四环素的 2-pass 排斥率可以达到 96.2%。新开发的一步简便涂层方法在制造用于制药行业 OSN 应用的膜方面具有巨大潜力。