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γδ TCR ligands: the quest to solve a 500-million-year-old mystery.
Nature Immunology ( IF 27.7 ) Pub Date : 2019-01-21 , DOI: 10.1038/s41590-018-0304-y Benjamin E Willcox 1 , Carrie R Willcox 2
Nature Immunology ( IF 27.7 ) Pub Date : 2019-01-21 , DOI: 10.1038/s41590-018-0304-y Benjamin E Willcox 1 , Carrie R Willcox 2
Affiliation
γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success.
中文翻译:
γδTCR配体:解决5亿年前的奥秘。
γδT细胞已在整个脊椎动物进化过程中作为谱系保留下来,能够以独特的方式应对免疫挑战,并且具有越来越高的治疗意义。然而,一个中心谜团一直存在:被γδT细胞抗原受体识别的配体的身份。在这里,我们讨论了回答这个问题的内在挑战,最新研究提供的新机会以及该领域判断成功的标准。
更新日期:2019-01-25
中文翻译:
γδTCR配体:解决5亿年前的奥秘。
γδT细胞已在整个脊椎动物进化过程中作为谱系保留下来,能够以独特的方式应对免疫挑战,并且具有越来越高的治疗意义。然而,一个中心谜团一直存在:被γδT细胞抗原受体识别的配体的身份。在这里,我们讨论了回答这个问题的内在挑战,最新研究提供的新机会以及该领域判断成功的标准。