Ferroptosis: The Greasy Side of Cell Death.,Chemical Research in Toxicology

当前位置： X-MOL 学术 › Chem. Res. Toxicol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Ferroptosis: The Greasy Side of Cell Death.
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2019-01-31 , DOI: 10.1021/acs.chemrestox.8b00349
José Pedro Friedmann Angeli ₁ , Sayuri Miyamoto ₂ , Almut Schulze ₃

Affiliation

Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidation in ferroptosis is highlighted by recent discoveries that demonstrate an intricate regulation of both the metabolism of polyunsaturated fatty acids as well as mechanisms leading to their oxidation. These metabolic steps converge at the point of ferroptosis execution through mechanisms that are now only starting to be understood. In this short review, we provide an appraisal of some of the recent advances in the understanding of the ferroptosis process and also provide some perspectives of where this knowledge could take us.

中文翻译：

Ferroptosis：细胞死亡的油腻面。

Ferroptosis是一种细胞死亡的形式，需要磷脂的过氧化作用，并引起了越来越多的关注，这既是根除对标准化学疗法有抵抗力的肿瘤的手段，也是其对组织损伤（例如在缺血/再灌注中）的潜在贡献。最近的发现突显了磷脂过氧化作用在肥大症中处于中心阶段，该发现表明对多不饱和脂肪酸的代谢以及导致其氧化的机制都有着复杂的调节作用。这些代谢步骤通过现在才刚刚开始被理解的机制在执行肥大病的时候收敛。在这篇简短的评论中，我们对在了解肥沃症的过程中取得的一些最新进展进行了评估，并对这些知识可以带给我们什么提供了一些观点。

更新日期：2019-01-17

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南