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Effect of intravitreal or sub-tenon triamcinolone acetonide injection at completion of vitrectomy on peripheral retinochoroidal thickness in eyes with proliferative diabetic retinopathy.
Scientific Reports ( IF 3.8 ) Pub Date : 2019-01-17 , DOI: 10.1038/s41598-018-37220-3 Yoshito Fujiwara 1 , Takeshi Iwase 1 , Kentaro Yamamoto 1 , Yoshitaka Ueno 1 , Eimei Ra 1 , Hiroko Terasaki 1
Scientific Reports ( IF 3.8 ) Pub Date : 2019-01-17 , DOI: 10.1038/s41598-018-37220-3 Yoshito Fujiwara 1 , Takeshi Iwase 1 , Kentaro Yamamoto 1 , Yoshitaka Ueno 1 , Eimei Ra 1 , Hiroko Terasaki 1
Affiliation
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The effect of triamcinolone acetonide (TA) on the peripheral retinochoroidal thickness was determined after pars plana vitrectomy (PPV) with scatter photocoagulation in eyes with proliferative diabetic retinopathy. The peripheral retinochoroidal thickness was measured at 5 mm from the limbus in the four quadrants using anterior segment optical coherence tomography before, and 3 days, and 1 and 2 weeks after the surgery. The total peripheral thickness was significantly thicker than the baseline thickness after PPV alone (P < 0.001; 18 eyes), PPV combined with intravitreal TA injection (IVTA; P = 0.011; 19 eyes), and PPV combined with sub-tenon TA injection (STTA; P = 0001; 23 eyes). The total peripheral thickness in the PPV group at 3 days after surgery was significantly thicker than that of the PPV + IVTA (P = 0.015) and of the PPV + STTA groups (P = 0.016). Multiple linear regression analyses showed that the injection of TA by the two routes and the number of photocoagulation burns were significantly correlated with the total peripheral thicknesses at 3 days after the surgery. The results indicate that the PPV with large number of intraoperative scatter photocoagulation burns caused an increase in the total peripheral thickness and an administration of either IVTA and STTA can reduced the degree of thickening.
中文翻译：
玻璃体切除术完成后玻璃体内或肌腱下注射曲安奈德丙酮对患有增生性糖尿病性视网膜病的眼睛外周脉络膜脉络膜厚度的影响。
在患有增生性糖尿病性视网膜病的眼睛中，经pars平板玻璃体切除术（PPV）散射光凝后，测定曲安奈德（TA）对周围视网膜脉络膜厚度的影响。在手术前，手术后3天，手术后1和2周，使用前节光学相干断层扫描在四个象限距角膜缘5 mm处测量外周脉络膜厚度。总外周厚度明显比单独使用PPV（P <0.001; 18眼），PPV联合玻璃体内TA注射（IVTA; P = 0.011; 19眼）和PPV联合筋膜下TA注射后的基线厚度要厚（P <0.001; 18眼）。 STTA； P = 0001； 23眼）。术后3天，PPV组的总外周厚度明显比PPV + IVTA的总厚度（P = 0。015）和PPV + STTA组（P = 0.016）。多元线性回归分析显示，两种途径的TA注射和光凝烧伤次数与术后3天的总外周厚度显着相关。结果表明，术中大量散布光凝性烧伤的PPV导致总外周厚度增加，同时给予IVTA和STTA均可降低增厚程度。
更新日期：2019-01-17
中文翻译：
玻璃体切除术完成后玻璃体内或肌腱下注射曲安奈德丙酮对患有增生性糖尿病性视网膜病的眼睛外周脉络膜脉络膜厚度的影响。
在患有增生性糖尿病性视网膜病的眼睛中，经pars平板玻璃体切除术（PPV）散射光凝后，测定曲安奈德（TA）对周围视网膜脉络膜厚度的影响。在手术前，手术后3天，手术后1和2周，使用前节光学相干断层扫描在四个象限距角膜缘5 mm处测量外周脉络膜厚度。总外周厚度明显比单独使用PPV（P <0.001; 18眼），PPV联合玻璃体内TA注射（IVTA; P = 0.011; 19眼）和PPV联合筋膜下TA注射后的基线厚度要厚（P <0.001; 18眼）。 STTA； P = 0001； 23眼）。术后3天，PPV组的总外周厚度明显比PPV + IVTA的总厚度（P = 0。015）和PPV + STTA组（P = 0.016）。多元线性回归分析显示，两种途径的TA注射和光凝烧伤次数与术后3天的总外周厚度显着相关。结果表明，术中大量散布光凝性烧伤的PPV导致总外周厚度增加，同时给予IVTA和STTA均可降低增厚程度。
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