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Rapidly separable microneedle patch for the sustained release of a contraceptive.
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2019-01-14 , DOI: 10.1038/s41551-018-0337-4 Wei Li 1 , Richard N Terry 1 , Jie Tang 2 , Meihua R Feng 2 , Steven P Schwendeman 2 , Mark R Prausnitz 1
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2019-01-14 , DOI: 10.1038/s41551-018-0337-4 Wei Li 1 , Richard N Terry 1 , Jie Tang 2 , Meihua R Feng 2 , Steven P Schwendeman 2 , Mark R Prausnitz 1
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Women often have limited access to contraception, and barrier methods have low acceptance and a high failure rate, mostly due to incorrect use, which can result in unplanned pregnancies. Sustained-release formulations of contraceptive hormones are available, yet typically require their administration by trained personnel. Here, we report the design of a microneedle patch with rapidly separable biodegradable polylactic acid and polylactic-co-glycolic acid needles, and its application for the continuous release of levonorgestrel-a contraceptive hormone. Bubble structures between each microneedle and the patch backing allow the microneedles to efficiently penetrate skin under compression, and to snap off under shear within five seconds after patch administration. In rats, the microneedle patch was well tolerated, leaving little visible evidence of use, and maintained plasma concentrations of the hormone above the human therapeutic level for one month. Further development of the rapidly separable microneedle patch for self-administered, long-acting contraception could enable women to better control their fertility.
中文翻译：
可快速分离的微针贴剂，用于持续释放避孕药具。
妇女往往难以获得避孕药具，隔离方法接受率低和失败率高，这主要是由于使用不当造成的，这可能导致计划外的怀孕。有避孕激素的缓释制剂，但通常需要经过培训的人员进行管理。在这里，我们报道了具有快速可分离的可生物降解的聚乳酸和聚乳酸-co-乙醇酸针头的微针贴剂的设计及其在持续释放左炔诺孕酮（一种避孕激素）中的应用。每个微针和贴剂背衬之间的气泡结构可使微针在受压下有效穿透皮肤，并在贴剂施用后五秒钟内在剪切力下折断。在大鼠中，微针贴片的耐受性良好，几乎没有可见的使用证据，并且该激素的血浆浓度在人类治疗水平以上维持了一个月。自行开发，长效避孕的快速可分离微针贴片的进一步开发可以使妇女更好地控制自己的生育能力。
更新日期：2019-01-26
中文翻译：
可快速分离的微针贴剂，用于持续释放避孕药具。
妇女往往难以获得避孕药具，隔离方法接受率低和失败率高，这主要是由于使用不当造成的，这可能导致计划外的怀孕。有避孕激素的缓释制剂，但通常需要经过培训的人员进行管理。在这里，我们报道了具有快速可分离的可生物降解的聚乳酸和聚乳酸-co-乙醇酸针头的微针贴剂的设计及其在持续释放左炔诺孕酮（一种避孕激素）中的应用。每个微针和贴剂背衬之间的气泡结构可使微针在受压下有效穿透皮肤，并在贴剂施用后五秒钟内在剪切力下折断。在大鼠中，微针贴片的耐受性良好，几乎没有可见的使用证据，并且该激素的血浆浓度在人类治疗水平以上维持了一个月。自行开发，长效避孕的快速可分离微针贴片的进一步开发可以使妇女更好地控制自己的生育能力。
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