The genetic basis of inbreeding depression in potato.,Nature Genetics

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The genetic basis of inbreeding depression in potato.
Nature Genetics ( IF 31.7 ) Pub Date : 2019-Jan-14 , DOI: 10.1038/s41588-018-0319-1
Chunzhi Zhang _{1,

2,

3} , Pei Wang ₁ , Die Tang ₂ , Zhongmin Yang ₄ , Fei Lu ₅ , Jianjian Qi ₆ , Nilesh R Tawari ₇ , Yi Shang ₁ , Canhui Li ₁ , Sanwen Huang _{2,

3}

Affiliation

Inbreeding depression confers reduced fitness among the offspring of genetic relatives. As a clonally propagated crop, potato (Solanum tuberosum L.) suffers from severe inbreeding depression; however, the genetic basis of inbreeding depression in potato is largely unknown. To gain insight into inbreeding depression in potato, we evaluated the mutation burden in 151 diploid potatoes and obtained 344,831 predicted deleterious substitutions. The deleterious mutations in potato are enriched in the pericentromeric regions and are line specific. Using three F₂ populations, we identified 15 genomic regions with severe segregation distortions due to selection at the gametic and zygotic stages. Most of the deleterious recessive alleles affecting survival and growth vigor were located in regions with high recombination rates. One of these deleterious alleles is derived from a rare mutation that disrupts a gene required for embryo development. This study provides the basis for genome design of potato inbred lines.

中文翻译：

马铃薯近交衰退的遗传基础。

近交衰退导致遗传亲属后代的适应性降低。作为一种无性繁殖作物，马铃薯（Solanum tuberosum L.）遭受严重的近交衰退；然而，马铃薯近交衰退的遗传基础在很大程度上是未知的。为了深入了解马铃薯的近交衰退，我们评估了 151 个二倍体马铃薯的突变负担，并获得了 344,831 个预测的有害替代。马铃薯中的有害突变在着丝粒周围区域富集并且是系特异性的。使用三个 F ₂由于在配子和合子阶段的选择，我们确定了 15 个具有严重分离扭曲的基因组区域。大多数影响生存和生长活力的有害隐性等位基因位于重组率高的区域。这些有害等位基因之一来自一种罕见的突变，该突变破坏了胚胎发育所需的基因。该研究为马铃薯自交系的基因组设计提供了依据。

更新日期：2019-01-25

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