A Radical Approach to Thioester-Containing Polymers,Journal of the American Chemical Society

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A Radical Approach to Thioester-Containing Polymers
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2019-01-12 , DOI: 10.1021/jacs.8b12154
Ronald A. Smith ₁ , Guanyao Fu ₁ , Owen McAteer ₁ , Mizhi Xu ₁ , Will R. Gutekunst ₁

Affiliation

A new approach to radical ring-opening polymerization is presented that employs a new thionolactone monomer to generate polymers with thioester-containing backbones. The use of a thiocarbonyl acceptor overcomes longstanding reactivity problems in the field to give complete ring-opening and quantitative incorporation into a variety of acrylate polymers. The resulting copolymers readily degrade under hydrolytic conditions, in addition to cysteine-mediated degradation through transthioesterification. The strategy is compatible with reversible addition-fragmentation chain transfer (RAFT) polymerization and permits the synthesis of block polymers for the preparation of well-defined macromolecular structures.

中文翻译：

含硫酯聚合物的激进方法

提出了一种自由基开环聚合的新方法，该方法使用一种新的硫代内酯单体来生成具有含硫酯主链的聚合物。硫代羰基受体的使用克服了该领域长期存在的反应性问题，以实现完全开环和定量结合到各种丙烯酸酯聚合物中。除了通过硫代酯转移进行半胱氨酸介导的降解外，所得共聚物在水解条件下很容易降解。该策略与可逆加成断裂链转移 (RAFT) 聚合兼容，并允许合成嵌段聚合物以制备明确定义的大分子结构。

更新日期：2019-01-12

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