Glutamate as an Efficient Amine Donor for the Synthesis of Chiral β‐ and γ‐Amino Acids Using Transaminase,ChemCatChem

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Glutamate as an Efficient Amine Donor for the Synthesis of Chiral β‐ and γ‐Amino Acids Using Transaminase
ChemCatChem ( IF 3.8 ) Pub Date : 2019-01-31 , DOI: 10.1002/cctc.201802048
Geon‐Hee Kim ₁ , Hyunwoo Jeon ₁ , Taresh P. Khobragade ₁ , Mahesh D. Patil ₁ , Sihyong Sung ₁ , Sanghan Yoon ₁ , Yumi Won ₁ , Sharad Sarak ₁ , Hyungdon Yun ₁

Affiliation

A recyclable glutamate amine donor system employing transaminase (TA), glutamate dehydrogenase (GluDH) and mutant formate dehydrogenase (FDHm) was developed, wherein amine donor Glu was regenerated using GluDH and thereby circumvented the inhibition of TA by α‐ketoglutarate. Various enantiopure β‐, γ‐amino acids, and amines were successfully synthesized with high conversions and excellent enantiomeric excess using this system.

中文翻译：

谷氨酸作为高效氨基供体，可利用转氨酶合成手性β-和γ-氨基酸

开发了一种利用转氨酶（TA），谷氨酸脱氢酶（GluDH）和突变型甲酸脱氢酶（FDHm）的可回收谷氨酸胺供体系统，其中使用GluDH再生了胺供体Glu，从而避免了α-酮戊二酸对TA的抑制作用。使用该系统成功合成了各种对映体纯的β-，γ-氨基酸和胺，具有高转化率和出色的对映体过量。

更新日期：2019-01-31

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