Synthetic Biology of Yeast.,Biochemistry

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Synthetic Biology of Yeast.
Biochemistry ( IF 2.9 ) Pub Date : 2019-01-23 , DOI: 10.1021/acs.biochem.8b01236
Zihe Liu ₁ , Yueping Zhang ₁ , Jens Nielsen _{1,

2,

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Affiliation

With the rapid development of DNA synthesis and next-generation sequencing, synthetic biology that aims to standardize, modularize, and innovate cellular functions, has achieved vast progress. Here we review key advances in synthetic biology of the yeast Saccharomyces cerevisiae, which serves as an important eukaryal model organism and widely applied cell factory. This covers the development of new building blocks, i.e., promoters, terminators and enzymes, pathway engineering, tools developments, and gene circuits utilization. We will also summarize impacts of synthetic biology on both basic and applied biology, and end with further directions for advancing synthetic biology in yeast.

中文翻译：

酵母的合成生物学。

随着DNA合成和下一代测序技术的飞速发展，旨在标准化，模块化和创新细胞功能的合成生物学取得了长足的进步。在这里，我们综述了酿酒酵母酵母的合成生物学方面的重要进展，酿酒酵母是重要的真核生物模型和广泛应用的细胞工厂。这涵盖了新构件的开发，即启动子，终止子和酶，途径工程，工具开发和基因回路利用。我们还将总结合成生物学对基础生物学和应用生物学的影响，并以进一步的路线指导酵母中合成生物学的发展。

更新日期：2019-01-08

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