Cobalt-Catalyzed, Hydroxyl-Assisted C–H Bond Functionalization: Access to Diversely Substituted Polycyclic Pyrans,The Journal of Organic Chemistry

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Cobalt-Catalyzed, Hydroxyl-Assisted C–H Bond Functionalization: Access to Diversely Substituted Polycyclic Pyrans
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2019-01-04 00:00:00 , DOI: 10.1021/acs.joc.8b02446
Pratip K. Dutta ₁ , Mahesh Kumar Ravva ₂ , Subhabrata Sen _{1,

2}

Affiliation

Highly efficient oxidative annulation of alkynes furnished diversely substituted pyran[2,3,4-de]chromene-2-one derivatives and related polycycles in moderate to high yield. The reaction is catalyzed by nontoxic, air-stable, and inexpensive Cp*Co(CO)I₂ catalyst. The hydroxyl moiety at the substrate acts as the directing group for the C–H bond activation.

中文翻译：

钴催化的羟基协助的C–H键官能化：获得不同取代的多环吡喃的方法

炔烃的高效氧化环化反应可提供中等至高收率的各种取代的吡喃[ 2,3,4- de ]色烯-2-酮衍生物和相关的多环。该反应由无毒，空气稳定且廉价的Cp * Co（CO）I ₂催化剂催化。底物上的羟基部分充当C–H键活化的指导基团。

更新日期：2019-01-04

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