Injectable, Self-Healing, and Multi-Responsive Hydrogels via Dynamic Covalent Bond Formation between Benzoxaborole and Hydroxyl Groups.,Biomacromolecules

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Injectable, Self-Healing, and Multi-Responsive Hydrogels via Dynamic Covalent Bond Formation between Benzoxaborole and Hydroxyl Groups.
Biomacromolecules ( IF 5.5 ) Pub Date : 2019-01-11 , DOI: 10.1021/acs.biomac.8b01652
Yangjun Chen _{1,

2} , Zhengzhong Tan _{2,

3} , Wenda Wang ₂ , Yi-Yang Peng ₂ , Ravin Narain ₂

Affiliation

Hydrogels that are injectable, self-healing, and multiresponsive are becoming increasingly relevant for a wide range of applications. In this work, we have successfully developed a novel approach in the fabrication of smart hydrogels with all the above properties. A symmetrical ABA triblock copolymer was first synthesized via atom transfer radical polymerization with a temperature responsive middle block and two permanently hydrophilic glycopolymer chains on both ends. Hydrogels were subsequently constructed by mixing the triblock copolymer with another linear hydrophilic copolymer bearing benzoxaborole groups. The interactions of the benzoxaborole groups with the sugar hydroxyl groups allowed the formation of dynamic covalent bonds. The resulting hydrogels exhibited temperature, pH, and sugar responsiveness. Rheological studies confirmed that the mechanical property can be tuned by changing the pH as well as the galactose/benzoxaborole molar ratio. Furthermore, the hydrogels showed excellent self-healing ability and shear-thinning performance due to the inherent well-known dynamic covalent bonds of boronic esters. Therefore, these types of hydrogels can have excellent biomedical applications.

中文翻译：

通过苯并氧杂硼烷和羟基之间的动态共价键形成的可注射，自愈和多反应水凝胶。

可注射，自愈和多反应的水凝胶对于广泛的应用变得越来越重要。在这项工作中，我们成功地开发了一种具有上述所有特性的新型智能水凝胶制造方法。首先通过原子转移自由基聚合反应合成对称的ABA三嵌段共聚物，该反应具有温度响应性中间嵌段和两个末端的两个永久亲水性糖聚合物链。随后通过将三嵌段共聚物与另一种带有苯并氧杂硼烷基的线性亲水性共聚物混合来构建水凝胶。苯并氧杂硼烷基与糖羟基的相互作用允许形成动态共价键。所得的水凝胶显示出温度，pH和糖响应性。流变学研究证实，可以通过改变pH值以及半乳糖/苯并氧杂硼酸酯的摩尔比来调节机械性能。此外，由于硼酸酯固有的众所周知的动态共价键，水凝胶显示出优异的自愈能力和剪切稀化性能。因此，这些类型的水凝胶可以具有出色的生物医学应用。

更新日期：2018-12-31

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