One-Step Fabrication of a Multifunctional Aggregation-Induced Emission Nanoaggregate for Targeted Cell Imaging and Enzyme-Triggered Cancer Chemotherapy,ACS Macro Letters

当前位置： X-MOL 学术 › ACS Macro Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

One-Step Fabrication of a Multifunctional Aggregation-Induced Emission Nanoaggregate for Targeted Cell Imaging and Enzyme-Triggered Cancer Chemotherapy
ACS Macro Letters ( IF 5.1 ) Pub Date : 2016-03-17 00:00:00 , DOI: 10.1021/acsmacrolett.6b00154
Bang-Ping Jiang ₁ , Xueyou Tan ₁ , Xing-Can Shen ₁ , Wen-Qi Lei ₁ , Wen-Qian Liang ₁ , Shi-Chen Ji ₁ , Hong Liang ₁

Affiliation

A novel multifunctional aggregation-induced emission (AIE) nanoaggregate for targeted imaging and enzyme-triggered chemotherapy was successfully fabricated via a one-step assembly. In this system, a quaternary ammonium-modified tetraphenylethene derivative (QA-TPE) acted as the AIE fluorophore as well as the chemotherapeutic agent, and a water-soluble acidic polysaccharide, hyaluronic acid (HA) acted as the aggregation-inducing scaffold, AIE turn-on agent, and targeting agent for CD44 receptor-mediated cancer cells. More importantly, HA endowed the QA-TPE/HA nanoaggregate both good biocompatibility and hysteretic chemotherapy activity, which were achieved by controlling the release of QA-TPE using the endogenous HAase in CD44 receptor-mediated cancer cells.

中文翻译：

用于靶向细胞成像和酶触发癌症化疗的多功能聚集诱导发射纳米聚集体的一步制造

通过一步组装成功地制造了一种用于靶向成像和酶触发化疗的新型多功能聚集诱导发射 (AIE) 纳米聚集体。在该系统中，季铵改性四苯基乙烯衍生物 (QA-TPE) 作为 AIE 荧光团和化疗剂，水溶性酸性多糖透明质酸 (HA) 作为聚集诱导支架 AIE CD44受体介导的癌细胞的开启剂和靶向剂。更重要的是，HA 赋予 QA-TPE/HA 纳米聚集体良好的生物相容性和滞后化疗活性，这是通过使用 CD44 受体介导的癌细胞中的内源性 HAase 控制 QA-TPE 的释放来实现的。

更新日期：2016-03-17

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南