AgSbF6-Catalyzed anti-Markovnikov hydroboration of terminal alkynes†,Chemical Communications

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AgSbF6-Catalyzed anti-Markovnikov hydroboration of terminal alkynes†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-12-21 00:00:00 , DOI: 10.1039/c8cc07499b
Ramesh Mamidala _{1,

2,

3,

4} , Vipin K. Pandey _{1,

2,

3,

4} , Arnab Rit _{1,

2,

3,

4}

Affiliation

AgSbF₆-Catalyzed anti-Markovnikov addition of pinacolborane (HBpin) to terminal alkynes to produce the E-vinylboronates is reported. This efficient methodology is scalable, compatible with sterically and electronically diverse alkynes, and works at room temperature under solvent-free condition. The utility of this method is demonstrated in the facile synthesis of the clinically important (E)-2,4,3′,5′-tetramethoxystilbene.

中文翻译：

AgSbF _6-末端炔烃的催化反马氏水硼化†

报道了在末端炔烃中AgSbF _6-催化的潘可可硼烷（HBpin）的抗-Markovnikov加成以产生E-乙烯基硼酸酯。这种有效的方法是可扩展的，可与空间和电子多样化的炔烃兼容，并且可在室温下于无溶剂条件下工作。该方法的实用性在临床上很重要的（E）-2,4,3'，5'-四甲氧基sti的简便合成中得到了证明。

更新日期：2018-12-21

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