Lipid Nanovesicles by Microfluidics: Manipulation, Synthesis, and Drug Delivery.,Advanced Materials

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Lipid Nanovesicles by Microfluidics: Manipulation, Synthesis, and Drug Delivery.
Advanced Materials ( IF 27.4 ) Pub Date : 2018-12-20 , DOI: 10.1002/adma.201804788
Chao Liu _{1,

2} , Qiang Feng _{1,

2} , Jiashu Sun _{1,

2}

Affiliation

Lipid nanovesicles, including endogenous exosomes and synthetic lipid nanoparticles, have shown great potential in disease diagnostics, drug delivery, and cancer biology. Naturally secreted nanovesicles are promising biomarkers for early detection of cancers in vitro. Synthetic nanovesicles serve as robust drug delivery systems with enhanced tumor targeting in vivo. Microfluidic platforms with features of excellent flow control and rapid mixing are exploited as versatile tools for studying lipid nanovesicles of small sizes and delicate structures. Here, an overview of microfluidics for precise manipulation and synthesis of lipid nanovesicles is provided. The mechanisms of isolation and detection of exosomes in microfluidics, as well as the clinical utility of exosomes for cancer diagnosis, are discussed. Several microfluidic designs for controlled assembly of a variety of lipid nanovesicles are highlighted. Opportunities and outstanding challenges of microfluidics-based investigation of lipid nanovesicles are discussed.

中文翻译：

脂质纳米囊泡的微流控：操纵，合成和药物输送。

脂质纳米囊泡，包括内源性外来体和合成脂质纳米颗粒，在疾病诊断，药物输送和癌症生物学中显示出巨大潜力。天然分泌的纳米囊泡是用于体外早期检测癌症的有前途的生物标志物。合成的纳米囊泡可作为具有增强的体内肿瘤靶向性的强大的药物输送系统。具有出色的流量控制和快速混合功能的微流体平台被用作研究小尺寸和精细结构的脂质纳米囊泡的多功能工具。在此，提供了用于脂质纳米囊泡的精确操纵和合成的微流控技术的概述。讨论了微流控中外泌体的分离和检测机制，以及外泌体在癌症诊断中的临床应用。着重介绍了用于多种脂质纳米囊泡可控组装的几种微流控设计。讨论了基于微流体的脂质纳米囊泡研究的机遇和突出挑战。

更新日期：2019-11-06

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