Synthesis of triazole linked macrocycles grafted with glyco-pyrrolidine/pyrrolizidine/thiazolidine/indolizine has been accomplished by one-pot sequential Huisgen cycloaddition and intramolecular azomethine ylide cycloaddition. The reaction involves the simultaneous formation of five bonds in one-pot to construct complex chiral macrocycles from the easily available starting materials. The structures of the macrocycles were confirmed by spectroscopic methods and X-ray crystallographic analysis.

中文翻译：

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一锅顺序叠氮化物-炔/分子间甲亚胺叶立德1,3-偶极环加成策略用于合成碳水化合物接枝的大环化合物

通过一锅顺序的Huisgen环加成和分子内的偶氮甲碱叶立德环加成反应，已完成了嫁接到糖吡咯烷/吡咯嗪/噻唑烷/吲哚嗪的三唑连接大环的合成。该反应涉及在一锅中同时形成五个键，以从容易获得的起始原料构建复杂的手性大环。大环的结构通过光谱法和X射线晶体学分析证实。