In this article, we describe a safe and practical process for the synthesis of 5-nitro-1,4-dihydro-1,4-methanonaphthalene (1) via a continuous-flow reactor. The primary procedures in this process involved not merely the production of isoamyl nitrite but also the temperature-programmed Diels–Alder reaction of an aryne (derived from 2-amino-6-nitrobenzoic acid) with cyclopentadiene in the series flow reactor. The continuous-flow process minimized the accumulation of dangerous isoamyl nitrite and the energetic diazonium salt, and the entire reaction time was held down to 250 s.

中文翻译：

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连续流法合成5-硝基-1,4-二氢-1,4-甲基萘

在本文中，我们描述了一种通过连续流反应器合成5-硝基-1,4-二氢-1,4-甲基萘（1）的安全实用的方法。该方法的主要步骤不仅涉及亚硝酸异戊酯的生产，还涉及串联流反应器中芳烃（衍生自2-氨基-6-硝基苯甲酸）与环戊二烯的温控狄尔斯-阿尔德反应。连续流过程将危险的亚硝酸异戊酯和高能重氮盐的积累降至最低，整个反应时间保持在250 s。