Continuous-Flow Process for the Synthesis of 5-Nitro-1,4-dihydro-1,4-methanonaphthalene,Organic Process Research & Development

当前位置： X-MOL 学术 › Org. Process Res. Dev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Continuous-Flow Process for the Synthesis of 5-Nitro-1,4-dihydro-1,4-methanonaphthalene
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-12-20 00:00:00 , DOI: 10.1021/acs.oprd.8b00281
Zhiyong Tan ₁ , Zhenhua Li ₁ , Guoqiang Jin ₁ , Chuanming Yu ₂

Affiliation

In this article, we describe a safe and practical process for the synthesis of 5-nitro-1,4-dihydro-1,4-methanonaphthalene (1) via a continuous-flow reactor. The primary procedures in this process involved not merely the production of isoamyl nitrite but also the temperature-programmed Diels–Alder reaction of an aryne (derived from 2-amino-6-nitrobenzoic acid) with cyclopentadiene in the series flow reactor. The continuous-flow process minimized the accumulation of dangerous isoamyl nitrite and the energetic diazonium salt, and the entire reaction time was held down to 250 s.

中文翻译：

连续流法合成5-硝基-1,4-二氢-1,4-甲基萘

在本文中，我们描述了一种通过连续流反应器合成5-硝基-1,4-二氢-1,4-甲基萘（1）的安全实用的方法。该方法的主要步骤不仅涉及亚硝酸异戊酯的生产，还涉及串联流反应器中芳烃（衍生自2-氨基-6-硝基苯甲酸）与环戊二烯的温控狄尔斯-阿尔德反应。连续流过程将危险的亚硝酸异戊酯和高能重氮盐的积累降至最低，整个反应时间保持在250 s。

更新日期：2018-12-20

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南