Tandem Cyclization/Hydroarylation of α,ω-Dienes Triggered by Scandium-Catalyzed C–H Activation,ACS Catalysis

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Tandem Cyclization/Hydroarylation of α,ω-Dienes Triggered by Scandium-Catalyzed C–H Activation
ACS Catalysis ( IF 11.3 ) Pub Date : 2018-12-18 00:00:00 , DOI: 10.1021/acscatal.8b04713
Bin Tang ₁ , Xiaoyan Hu ₁ , Chunli Liu ₁ , Tao Jiang ₁ , Fakhre Alam ₁ , Yanhui Chen ₁

Affiliation

A highly regio- and diastereoselective cyclization/hydroarylation reaction of 1,5- and 1,6-dienes with aromatic ethers and tertiary anilines was established by a cationic 2-picoline-tethered-half-sandwich scandium alkyl catalyst, which constitutes a process for producing a diverse array of cis-1,3-disubstituted arylated and trans-1,2-disubstituted benzylated methylcyclopentane derivatives in one step with 100% atom-efficiency. Furthermore, a mechanism involving a scandium-catalyzed aromatic ortho-C–H activation and alkene-insertion cascade was also proposed.

中文翻译：

Scan催化的CH活化激活α，ω-二烯的串联环化/氢化芳基化

1，5-和1，6-二烯与芳族醚和叔苯胺的高度区域和非对映选择性环化/氢芳基化反应是通过阳离子2-甲基吡啶系留的半三明治s烷基烷基催化剂建立的，一步以100％的原子效率生产多种顺式-1,3-二取代的芳基化和反式-1,2-二取代的苄基化甲基环戊烷衍生物。此外，还提出了涉及involving催化的芳族邻-C-H活化和烯烃插入级联反应的机理。

更新日期：2018-12-18

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