Evaluation of inert gas rebreathing for determination of cardiac output: influence of age, gender and body size,Hypertension Research

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Evaluation of inert gas rebreathing for determination of cardiac output: influence of age, gender and body size
Hypertension Research ( IF 4.3 ) Pub Date : 2018-12-18 , DOI: 10.1038/s41440-018-0179-1
Jessica E Middlemiss ₁ , Alex Cocks ₁ , Kaido Paapstel ₂ , Kaisa M Maki-Petaja ₁ , Sunita ₁ , Ian B Wilkinson ₁ , Carmel M McEniery ₁ ,

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The aim of this study was to evaluate an inert gas rebreathing method (Innocor) for measurement of cardiac output and related haemodynamic variables and to provide robust normative data describing the influence of age, gender and body size on these variables. Four separate studies were conducted: measurement repeatability (study 1, n = 45); postural change (study 2, n = 40); response to submaximal cycling exercise (study 3, n = 20); and the influence of age, gender and body size (study 4, n = 1400). Repeated measurements of cardiac output, stroke volume and heart rate were similar, with low mean (±SD) differences (0.26 ± 0.53 L/min, 0 ± 11 mL and 2 ± 6beats/min, respectively). In addition, cardiac output and stroke volume both declined progressively from supine to seated and standing positions (P < 0.001 for both) and there was a stepwise increase in both parameters moving from rest to submaximal exercise (P < 0.001 for both). In study 4, there was a significant age-related decline in cardiac output and stroke volume in males and females, which remained significant after adjusting for body surface area (BSA, P < 0.001 for all comparisons). Both parameters were also significantly higher in those with high body mass index (BMI; P < 0.01 versus those with normal BMI for all comparisons), although indexing cardiac output and stroke volume to BSA reversed these trends. Inert gas rebreathing using the Innocor device provides repeatable measurements of cardiac output and related indices, which are sensitive to the effects of acute physiological manoeuvres. Moreover, inert gas rebreathing is a suitable technique for examining chronic influences such as age, gender and body size on key haemodynamic components of the arterial blood pressure.

中文翻译：

评估惰性气体再呼吸以确定心输出量：年龄、性别和体型的影响

本研究的目的是评估用于测量心输出量和相关血流动力学变量的惰性气体再呼吸方法 (Innocor)，并提供可靠的规范数据来描述年龄、性别和体型对这些变量的影响。进行了四项独立的研究：测量重复性（研究 1，n = 45）；姿势改变（研究 2，n = 40）；对次最大自行车运动的反应（研究 3，n = 20）；以及年龄、性别和体型的影响（研究 4，n = 1400）。心输出量、每搏输出量和心率的重复测量结果相似，平均 (±SD) 差异较低（分别为 0.26 ± 0.53 L/min、0 ± 11 mL 和 2 ± 6beats/min）。此外，从仰卧位到坐位和站立位，心输出量和每搏输出量均逐渐下降（P < 0. 001），并且从休息到次最大运动的两个参数都逐步增加（两者的 P < 0.001）。在研究 4 中，男性和女性的心输出量和每搏输出量均出现与年龄相关的显着下降，在调整体表面积后仍然显着（BSA，所有比较的 P < 0.001）。尽管将心输出量和每搏输出量与 BSA 挂钩可以逆转这些趋势，但在体重指数较高的人群中（BMI；P < 0.01 与所有比较中 BMI 正常的人群相比，这两个参数也显着升高）。使用 Innocor 装置进行的惰性气体再呼吸提供了对心输出量和相关指标的可重复测量，这些指标对急性生理动作的影响很敏感。而且，

更新日期：2018-12-18

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