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Circadian blueprint of metabolic pathways in the brain.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-02-01 , DOI: 10.1038/s41583-018-0096-y Carolina Magdalen Greco 1 , Paolo Sassone-Corsi 1
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-02-01 , DOI: 10.1038/s41583-018-0096-y Carolina Magdalen Greco 1 , Paolo Sassone-Corsi 1
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The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.
中文翻译：
大脑代谢途径的昼夜蓝图。
生物钟是一种内源性的时间跟踪系统，它指导体内平衡所需的多种代谢和生理功能。位于下丘脑视交叉上核内的主时钟或中央时钟控制着存在于所有全身组织中的外周时钟，有助于它们的排列并最终有助于生理的时间协调。越来越多的证据表明大脑中存在额外的时钟，并表明昼夜节律电路可能会从外围反馈给这些时钟。在这里，我们重点介绍时钟之间通信的最新进展，并讨论它们与昼夜节律生理和新陈代谢的关系。
更新日期：2019-01-26
中文翻译：
大脑代谢途径的昼夜蓝图。
生物钟是一种内源性的时间跟踪系统，它指导体内平衡所需的多种代谢和生理功能。位于下丘脑视交叉上核内的主时钟或中央时钟控制着存在于所有全身组织中的外周时钟，有助于它们的排列并最终有助于生理的时间协调。越来越多的证据表明大脑中存在额外的时钟，并表明昼夜节律电路可能会从外围反馈给这些时钟。在这里，我们重点介绍时钟之间通信的最新进展，并讨论它们与昼夜节律生理和新陈代谢的关系。
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