Rapid Access to Spirocylic Oxindoles: Application of Asymmetric N-Heterocyclic Carbene-Catalyzed [3 + 3] Cycloaddition of Imines to Oxindole-Derived Enals,Organic Letters

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Rapid Access to Spirocylic Oxindoles: Application of Asymmetric N-Heterocyclic Carbene-Catalyzed [3 + 3] Cycloaddition of Imines to Oxindole-Derived Enals
Organic Letters ( IF 4.9 ) Pub Date : 2015-05-04 00:00:00 , DOI: 10.1021/acs.orglett.5b00726
Danbo Xie ₁ , Limin Yang ₁ , Youqiang Lin ₁ , Zhiming Zhang ₁ , Dongdong Chen ₁ , Xiaofei Zeng ₁ , Guofu Zhong ₁

Affiliation

A chiral N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition reaction of imines and oxindole-derived enals was developed for rapid access to spirocylic oxindoles. In most cases, the desired spirocylic oxindole products were obtained in high yields and excellent enantioselectivities with less than 1 h of reaction time.

中文翻译：

快速获得螺羟基吲哚：亚胺的不对称N杂环碳烯催化的[3 + 3]环加成反应与环氧吲哚衍生的烯类的应用

开发了一种手性N-杂环卡宾（NHC）催化的亚胺和由羟吲哚衍生的烯类化合物的[3 + 3]环加成反应，可快速获得螺环式羟吲哚。在大多数情况下，只需不到1小时的反应时间，就可以以高收率和出色的对映选择性获得所需的螺环羟吲哚产物。

更新日期：2015-05-04

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