<br>细胞外囊泡与血清阳性类风湿性关节炎患者的全身炎症有关。,Scientific Reports

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细胞外囊泡与血清阳性类风湿性关节炎患者的全身炎症有关。
Scientific Reports ( IF 3.8 ) Pub Date : 2018-12-17 , DOI: 10.1038/s41598-018-36335-x
Catalina Burbano _{1,

2} , Mauricio Rojas _{1,

2} , Carlos Muñoz-Vahos ₃ , Adriana Vanegas-García ₃ , Luis A Correa ₄ , Gloria Vásquez ₁ , Diana Castaño ₁

Affiliation

患有类风湿性关节炎（RA）和自身抗体（例如类风湿因子和抗环瓜氨酸肽的抗体）的患者被指定为血清阳性，并且与血清阴性 RA 患者相比，病情更严重，预后更差。除了关节承诺之外，了解参与全身炎症的因素将为预防 RA 合并症和疾病复发提供更好的治疗方法。我们评估了单核细胞亚群和细胞外囊泡（EV）是否会导致这种现象。血清阳性患者的促炎细胞因子水平高于血清阴性患者和健康对照（HC）；然而，这种全身炎症特征与疾病活动无关。 IgG、IgM、CD41a 和瓜氨酸阳性的循环 EV 频率较高，加上中间单核细胞计数和受体表达的改变，与血清阳性患者的全身炎症有关；这些改变在血清阴性患者中没有观察到，这似乎与 HC 更相似。此外，来自血清阳性患者的EV能够在体外激活单核吞噬细胞，并诱导促炎细胞因子，这与血清阳性RA患者全身水平观察到的炎症反应相当。因此，所有这些因素都可能导致这些患者的疾病更加严重。

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Extracellular vesicles are associated with the systemic inflammation of patients with seropositive rheumatoid arthritis.

Patients with rheumatoid arthritis (RA) and autoantibodies, such as rheumatoid factor and those against cyclic citrullinated peptides, are designated as seropositive and have a more severe disease with worse prognosis than seronegative RA patients. Understanding the factors that participate in systemic inflammation, in addition to articular commitment, would allow better treatment approaches for prevention of RA comorbidities and disease reactivation. We evaluated whether monocyte subsets and extracellular vesicles (EVs) could contribute to this phenomenon. Seropositive patients had higher levels of proinflammatory cytokines than those of seronegative patients and healthy controls (HCs); however, this systemic inflammatory profile was unrelated to disease activity. High frequencies of circulating EVs positive for IgG, IgM, CD41a, and citrulline, together with altered counts and receptor expression of intermediate monocytes, were associated with systemic inflammation in seropositive patients; these alterations were not observed in seronegative patients, which seem to be more similar to HCs. Additionally, the EVs from seropositive patients were able to activate mononuclear phagocytes in vitro, and induced proinflammatory cytokines that were comparable to the inflammatory response observed at the systemic level in seropositive RA patients; therefore, all of these factors may contribute to the greater disease severity that has been described in these patients.

更新日期：2018-12-17

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