Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma.,Modern Pathology

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Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma.
Modern Pathology ( IF 7.1 ) Pub Date : 2018-12-14 , DOI: 10.1038/s41379-018-0188-2
Gabriela Acuña ₁ , Montserrat Gomà ₂ , Jordi Temprana-Salvador ₃ , Federico Garcia-Bragado ₄ , Llucia Alós ₅ , Jaume Ordi ₆ , Antonio Cardesa ₇ , Alfons Nadal ₅

Affiliation

The involvement of human papillomavirus (HPV) in laryngeal and hypopharyngeal lymphoepithelial carcinoma was investigated in a series of ten cases (seven laryngeal and three hypopharyngeal), retrieved from the files of three tertiary hospitals in the 2000-2017 period, through polymerase chain reaction with SPF10 primers and INNO-LiPA HPV Genotyping Extra II (Innogenetics). Epstein-Barr virus (EBV) was tested in all cases with in situ hybridization INFORM EBER Probe (Ventana Medical Systems). p16 and p53 expression were immunohistochemically analyzed. Calculated annual incidence was 0.013/100,000, and prevalence was 0.2% of laryngeal and hypopharyngeal carcinomas. All cases were EBV negative. HPV was detected in five cases, three of which also overexpressed p16. HPV16 was detected in four cases, and HPV58 in one case. Five cases were HPV negative, only one of these five overexpressed p16. No recurrence was observed in nine cases during follow-up. The 5-year disease-specific-survival rate was 100%. Mean overall survival was 87 months. Lymphoepithelial carcinoma of the larynx and hypopharynx are not related to EBV. Simultaneous HPV+/p16+ is consistent with HPV causation in a fraction of laryngeal and hypopharyngeal lymphoepithelial carcinomas.

中文翻译：

喉和下咽淋巴上皮癌中的人乳头瘤病毒。

人乳头瘤病毒 (HPV) 在喉和下咽淋巴上皮癌中的作用在 2000-2017 年期间从三家三级医院的档案中检索到的十个病例系列（七例喉癌和三例下咽癌）中进行了研究，通过聚合酶链反应与SPF10 引物和 INNO-LiPA HPV 基因分型 Extra II (Innogenetics)。在所有情况下都使用原位杂交 INFORM EBER 探针 (Ventana Medical Systems) 测试了爱泼斯坦-巴尔病毒 (EBV)。对 p16 和 p53 表达进行免疫组织化学分析。计算出的年发病率为 0.013/100,000，喉癌和下咽癌的患病率为 0.2%。所有病例均为 EBV 阴性。在 5 个病例中检测到 HPV，其中 3 个也过表达 p16。4例检出HPV16，1例检出HPV58。5 例 HPV 阴性，这五个中只有一个过表达 p16。9例随访未见复发。5 年疾病特异性生存率为 100%。平均总生存期为 87 个月。喉部和下咽部的淋巴上皮癌与 EBV 无关。在部分喉癌和下咽淋巴上皮癌中，同时感染 HPV+/p16+ 与 HPV 因果关系一致。

更新日期：2019-01-26

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