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Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow.
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2018-12-13 , DOI: 10.1021/acs.jmedchem.8b01682 Bingbing Ding 1, 2 , Yuling Xiao 1 , Hui Zhou 1 , Xiao Zhang 2 , Chunrong Qu 2 , Fuchun Xu 3 , Zixin Deng 1 , Zhen Cheng 2 , Xuechuan Hong 1, 3, 4
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2018-12-13 , DOI: 10.1021/acs.jmedchem.8b01682 Bingbing Ding 1, 2 , Yuling Xiao 1 , Hui Zhou 1 , Xiao Zhang 2 , Chunrong Qu 2 , Fuchun Xu 3 , Zixin Deng 1 , Zhen Cheng 2 , Xuechuan Hong 1, 3, 4
Affiliation
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Small-molecule fluorescence imaging in the second near-infrared (NIR-II, 1000-1700 nm) window has gained increasing interest in clinical application. Till now, very few studies have been exploited in the small-molecule fluorophores with both excitation and emission in the NIR-II window. Inspired by the indocyanine green structure, a series of polymethine dyes with both absorption and emission in the NIR-II window have been developed for NIR-II imaging, providing the feasibility to directly compare optical imaging in the NIR-IIa (1300-1400 nm) subwindow under 1064 nm excitation with that in the NIR-II window under 808 nm excitation. The signal-background ratio and the tumor-normal tissue ratio achieved great improvement under 1064 nm excitation in the imaging of mouse blood pool and U87 glioma tumors. Our study not only introduces a broadband emission fluorophore for both NIR-II and NIR-IIa imaging, but also reveals the advantages of NIR-II excitation over NIR-I in in vivo imaging.
中文翻译：
在第二个近红外子窗口中用于生物成像的吸收超过1000 nm的聚次甲基硫吡啶鎓荧光团。
在第二个近红外（NIR-II，1000-1700 nm）窗口中的小分子荧光成像已在临床应用中引起了越来越多的兴趣。迄今为止，在小分子荧光团中在NIR-II窗口中既有激发又有发射的研究很少。受吲哚菁绿色结构的启发，已开发出一系列在NIR-II窗口中具有吸收和发射的聚次甲基染料，用于NIR-II成像，从而提供了直接比较NIR-IIa（1300-1400 nm）光学成像的可行性）在1064 nm激发下的子窗口与在808 nm激发下的NIR-II窗口中的子窗口。在小鼠血池和U87神经胶质瘤肿瘤的成像中，在1064 nm激发下，信号背景比和肿瘤正常组织比得到了极大的改善。
更新日期：2018-12-02
中文翻译：
在第二个近红外子窗口中用于生物成像的吸收超过1000 nm的聚次甲基硫吡啶鎓荧光团。
在第二个近红外（NIR-II，1000-1700 nm）窗口中的小分子荧光成像已在临床应用中引起了越来越多的兴趣。迄今为止，在小分子荧光团中在NIR-II窗口中既有激发又有发射的研究很少。受吲哚菁绿色结构的启发，已开发出一系列在NIR-II窗口中具有吸收和发射的聚次甲基染料，用于NIR-II成像，从而提供了直接比较NIR-IIa（1300-1400 nm）光学成像的可行性）在1064 nm激发下的子窗口与在808 nm激发下的NIR-II窗口中的子窗口。在小鼠血池和U87神经胶质瘤肿瘤的成像中，在1064 nm激发下，信号背景比和肿瘤正常组织比得到了极大的改善。
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