Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy,Advanced Science

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Efficient Near Infrared Light Triggered Nitric Oxide Release Nanocomposites for Sensitizing Mild Photothermal Therapy
Advanced Science ( IF 14.3 ) Pub Date : 2018-12-11 , DOI: 10.1002/advs.201801122
Xiao Zhang ₁ , Jiangfeng Du ₂ , Zhao Guo _{1,

3} , Jie Yu _{1,

4} , Qin Gao ₁ , Wenyan Yin ₁ , Shuang Zhu ₁ , Zhanjun Gu _{1,

3} , Yuliang Zhao _{1,

3}

Affiliation

Mild photothermal therapy (PTT), as a new anticancer therapeutic strategy, faces big challenges of limited therapeutic accuracy and side‐effects due to uneven heat distribution. Here, near infrared triggered nitric oxide (NO) release nanocomposites based on bismuth sulfide (Bi₂S₃) nanoparticles and bis‐N‐nitroso compounds (BNN) are constructed for NO‐enhanced mild photothermal therapy. Upon 808 nm irradiation, the high photothermal conversion efficiency and on‐demand NO release are realized simultaneously. Due to the unique properties of NO, enhanced antitumor efficacy of mild PTT based on BNN‐Bi₂S₃ nanocomposites is achieved in vitro and in vivo. Mechanism studies reveal that the exogenous NO from BNN‐Bi₂S₃ could not only impair the autophagic self‐repairing ability of tumor cells in situ, but also diffuse to the surrounding cells to enhance the therapeutic effect. This work points out a strategy to overcome the difficulties in mild PTT, and has potentials for further exploitation of NO‐sensitized synergistic cancer therapy.

中文翻译：

用于敏化温和光热疗法的高效近红外光触发一氧化氮释放纳米复合材料

温和光热疗法（PTT）作为一种新的抗癌治疗策略，面临着治疗精度有限和由于热量分布不均匀而产生副作用的巨大挑战。在此，构建了基于硫化铋（Bi ₂ S ₃ ）纳米颗粒和双N-亚硝基化合物（BNN）的近红外触发一氧化氮（NO）释放纳米复合材料，用于NO增强温和光热疗法。在808 nm照射下，同时实现了高光热转换效率和按需释放NO。由于NO的独特性质，基于BNN-Bi ₂ S ₃纳米复合材料的温和PTT在体外和体内均实现了增强的抗肿瘤功效。机制研究表明，BNN-Bi ₂ S ₃中的外源性NO不仅可以原位损害肿瘤细胞的自噬自我修复能力，而且可以扩散到周围细胞以增强治疗效果。这项工作提出了克服轻度 PTT 困难的策略，并具有进一步开发 NO 敏化协同癌症治疗的潜力。

更新日期：2018-12-11

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