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Difunctionalization of the Isocyano Group: Atom-Economic Synthesis of Pyrimidinediones
Synlett ( IF 1.7 ) Pub Date : 2018-12-11 , DOI: 10.1055/s-0037-1610348 Jian Lang , Ye Wei 1
Synlett ( IF 1.7 ) Pub Date : 2018-12-11 , DOI: 10.1055/s-0037-1610348 Jian Lang , Ye Wei 1
Affiliation
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The exploration of synthetic methods involving the formation of new chemical bonds at both the nitrogen and carbons atoms of the isocyano group would largely enrich the structural diversity of compounds. Herein, we disclosed a silver-catalyzed difunctionalization of the isocyano group with cyclic oximes. This method can generate a great array of structurally novel and interesting pyrimidinediones and features excellent atom economy, good functional group compatibility, and amenability to late-stage modifications.
中文翻译：
异氰基的双官能化：嘧啶二酮的原子经济合成
探索涉及在异氰基的氮和碳原子上形成新化学键的合成方法将在很大程度上丰富化合物的结构多样性。在此，我们公开了异氰基与环状肟的银催化双官能化。该方法可以生成大量结构新颖且有趣的嘧啶二酮，并具有优异的原子经济性、良好的官能团兼容性和后期修饰的适应性。
更新日期：2018-12-11
中文翻译：
异氰基的双官能化：嘧啶二酮的原子经济合成
探索涉及在异氰基的氮和碳原子上形成新化学键的合成方法将在很大程度上丰富化合物的结构多样性。在此，我们公开了异氰基与环状肟的银催化双官能化。该方法可以生成大量结构新颖且有趣的嘧啶二酮，并具有优异的原子经济性、良好的官能团兼容性和后期修饰的适应性。
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