Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition,The Journal of Organic Chemistry

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Regioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-12-12 00:00:00 , DOI: 10.1021/acs.joc.8b02377
Priyanka Chaudhary ₁ , Surabhi Gupta ₁ , Nalluchamy Muniyappan ₂ , Shahulhameed Sabiah ₂ , Jeyakumar Kandasamy ₁

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Regioselective ring nitration of N-alkyl anilines is reported using tert-butyl nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, respectively.

中文翻译：

叔丁基亚硝酸盐在温和条件下对N-烷基苯胺的区域选择性硝化

据报道使用亚硝酸叔丁酯对N-烷基苯胺的区域选择性环硝化。该反应在多种底物下有效地进行，以优异的产率提供了合成上有用的N-亚硝基N-烷基硝基苯胺，可以分别使用Zn-AcOH和HCl / MeOH轻松地将其转化为N-烷基苯二胺和N-烷基硝基苯胺。

更新日期：2018-12-12

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