当前位置：
X-MOL 学术
›
Nat. Rev. Mol. Cell Biol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Dynamics and functions of lipid droplets.
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-03-01 , DOI: 10.1038/s41580-018-0085-z James A Olzmann 1 , Pedro Carvalho 2
Nature Reviews Molecular Cell Biology ( IF 81.3 ) Pub Date : 2019-03-01 , DOI: 10.1038/s41580-018-0085-z James A Olzmann 1 , Pedro Carvalho 2
Affiliation
|
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic reticulum, lipid droplets can associate with most other cellular organelles through membrane contact sites. It is becoming apparent that these contacts between lipid droplets and other organelles are highly dynamic and coupled to the cycles of lipid droplet expansion and shrinkage. Importantly, lipid droplet biogenesis and degradation, as well as their interactions with other organelles, are tightly coupled to cellular metabolism and are critical to buffer the levels of toxic lipid species. Thus, lipid droplets facilitate the coordination and communication between different organelles and act as vital hubs of cellular metabolism.
中文翻译：
脂滴的动力学和功能。
脂滴是脂质和能量稳态中心的储存细胞器。它们具有独特的结构，由中性脂质的疏水核心组成，该核心被由一组特定蛋白质装饰的磷脂单层包围。脂滴起源于内质网，可以通过膜接触位点与大多数其他细胞器结合。越来越明显的是，脂滴和其他细胞器之间的这些接触是高度动态的，并且与脂滴膨胀和收缩的循环耦合。重要的是，脂滴的生物发生和降解，以及它们与其他细胞器的相互作用，与细胞代谢紧密耦合，对于缓冲有毒脂质的水平至关重要。因此，脂滴促进不同细胞器之间的协调和沟通，并充当细胞代谢的重要枢纽。
更新日期：2019-05-16
中文翻译：
脂滴的动力学和功能。
脂滴是脂质和能量稳态中心的储存细胞器。它们具有独特的结构，由中性脂质的疏水核心组成，该核心被由一组特定蛋白质装饰的磷脂单层包围。脂滴起源于内质网，可以通过膜接触位点与大多数其他细胞器结合。越来越明显的是，脂滴和其他细胞器之间的这些接触是高度动态的，并且与脂滴膨胀和收缩的循环耦合。重要的是，脂滴的生物发生和降解，以及它们与其他细胞器的相互作用，与细胞代谢紧密耦合，对于缓冲有毒脂质的水平至关重要。因此，脂滴促进不同细胞器之间的协调和沟通，并充当细胞代谢的重要枢纽。
京公网安备 11010802027423号