Syntheses of 2-(2,2,2-trifluoroethylidene)/(2,2-difluoroethyl)-1,3-dicarbonyl compounds and their fungicidal activities†,Organic Chemistry Frontiers

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Syntheses of 2-(2,2,2-trifluoroethylidene)/(2,2-difluoroethyl)-1,3-dicarbonyl compounds and their fungicidal activities†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-12-07 00:00:00 , DOI: 10.1039/c8qo01118d
Yueji Chen _{1,

2,

3,

4,

5} , Yi You _{1,

2,

3,

4,

5} , Zhiqiang Weng _{1,

2,

3,

4,

5}

Affiliation

A Knoevenagel-type reaction of 1,3-diketone substrates with trifluoroacetic anhydride is described. The electrophilic species of trifluoroacetaldehyde is easily generated in situ by the reaction of trifluoroacetic anhydride/difluoroacetic anhydride with triethylamine. By this efficient and simple approach, a library of 2-(2,2,2-trifluoroethylidene)-1,3-dicarbonyl compounds that contain a wide range of functional groups were synthesized in good yields. Moreover, the reaction with difluoroacetic anhydride affords the corresponding (2,2-difluoroethyl)-1,3-dicarbonyls. Some of these compounds exhibited promising fungicidal activities.

中文翻译：

的2-（2,2,2-三氟亚乙基）/（2,2-二氟乙基）-1,3-合成二羰基化合物和它们的杀真菌活性†

描述了1，3-二酮底物与三氟乙酸酐的Knoevenagel型反应。通过三氟乙酸酐/二氟乙酸酐与三乙胺的反应，很容易就地生成三氟乙醛的亲电子物质。通过这种有效且简单的方法，以高收率合成了包含多种官能团的2-（2,2,2-三氟亚乙基）-1,3-二羰基化合物库。此外，与二氟乙酸酐的反应得到相应的（2，2-二氟乙基）-1，3-二羰基。这些化合物中的一些表现出有希望的杀真菌活性。

更新日期：2018-12-07

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