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Preparation of Heteroaryl Ethers from Azine N-Oxides and Alcohols
Organic Letters ( IF 4.9 ) Pub Date : 2016-03-09 00:00:00 , DOI: 10.1021/acs.orglett.6b00295
Yajing Lian 1 , Steven B. Coffey 1 , Qifang Li 1 , Allyn T. Londregan 1
Organic Letters ( IF 4.9 ) Pub Date : 2016-03-09 00:00:00 , DOI: 10.1021/acs.orglett.6b00295
Yajing Lian 1 , Steven B. Coffey 1 , Qifang Li 1 , Allyn T. Londregan 1
Affiliation
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The heteroaryl ether is an important structural feature in molecules of biological interest, yet it remains a challenge to synthesize. A new and practical method for the synthesis of heteroaryl ethers is reported. In the presence of PyBroP, a variety of nonaromatic alcohols readily add to azine N-oxides to afford the corresponding heteroaryl ethers. The reaction conditions are mild, economical, chemoselective, and compatible with a broad range of substrates. Thirty-eight examples are provided, as is a discussion of reaction optimization and mechanism.
中文翻译:
由叠氮N-氧化物和醇制备杂芳基醚
杂芳基醚是生物学上重要分子的重要结构特征,但合成仍然是一项挑战。报道了一种新的实用的合成杂芳基醚的方法。在PyBroP的存在下,各种非芳族醇容易地加到嗪N-氧化物中以提供相应的杂芳基醚。反应条件温和,经济,化学选择性,并与多种底物相容。提供了38个示例,以及对反应优化和机理的讨论。
更新日期:2016-03-09
中文翻译:
![](https://scdn.x-mol.com/jcss/images/paperTranslation.png)
由叠氮N-氧化物和醇制备杂芳基醚
杂芳基醚是生物学上重要分子的重要结构特征,但合成仍然是一项挑战。报道了一种新的实用的合成杂芳基醚的方法。在PyBroP的存在下,各种非芳族醇容易地加到嗪N-氧化物中以提供相应的杂芳基醚。反应条件温和,经济,化学选择性,并与多种底物相容。提供了38个示例,以及对反应优化和机理的讨论。