Concept and Development of Framework Nucleic Acids,Journal of the American Chemical Society

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Concept and Development of Framework Nucleic Acids
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2018-12-05 , DOI: 10.1021/jacs.8b10529
Zhilei Ge ₁ , Hongzhou Gu ₂ , Qian Li ₁ , Chunhai Fan _{1,

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Affiliation

The blooming field of structural DNA nanotechnology harnessing the material properties of nucleic acids has attracted widespread interest. The exploitation of the precise and programmable Watson-Crick base pairing of DNA or RNA has led to the development of exquisite nucleic acid nanostructures from one to three dimensions. The advances of computer-aided tools facilitate automated design of DNA nanostructures with various sizes and shapes. Especially, the construction of shell or skeleton DNA frameworks, or more recently dubbed "framework nucleic acids" (FNAs) provides a means to organize molecules or nanoparticles with nanometer precision. The intrinsic biological properties and tailorable functionalities of FNAs hold great promise for physical, chemical, and biological applications. This Perspective highlights state-of-the-art design and construction, of precisely assembled FNAs, and outlines the challenges and opportunities for exploiting the structural potential of FNAs for translational applications.

中文翻译：

框架核酸的概念与发展

利用核酸材料特性的结构 DNA 纳米技术的蓬勃发展领域引起了广泛的兴趣。对 DNA 或 RNA 的精确和可编程的 Watson-Crick 碱基配对的开发已经导致从一维到三维的精细核酸纳米结构的发展。计算机辅助工具的进步促进了各种尺寸和形状的 DNA 纳米结构的自动化设计。特别是，壳或骨架 DNA 框架的构建，或者最近被称为“框架核酸”（FNA），提供了一种以纳米精度组织分子或纳米粒子的方法。FNA 的内在生物学特性和可定制的功能在物理、化学和生物学应用中具有广阔的前景。

更新日期：2018-12-05

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