Synthesis ( IF 2.2 ) Pub Date : 2018-12-03 , DOI: 10.1055/s-0037-1611355
Guang-Jian Mei 1 , Feng Shi 1 , Lei Yu , Zi-Qi Zhu , Meng Sun
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Abstract
An iridium-catalyzed branch-selective ring-opening reaction of vinylcyclopropanes with indoles has been established, which afforded C3-allylindoles in generally good to excellent yields (up to 95%). Considering that no wastes were generated in the whole process and branch-selective ring-opening reaction of vinylcyclopropanes was rarely reported, this strategy not only can be regarded as a highly atom-economic approach for C3-allylindoles, but also will greatly enrich the chemistry of vinylcyclopropanes.
An iridium-catalyzed branch-selective ring-opening reaction of vinylcyclopropanes with indoles has been established, which afforded C3-allylindoles in generally good to excellent yields (up to 95%). Considering that no wastes were generated in the whole process and branch-selective ring-opening reaction of vinylcyclopropanes was rarely reported, this strategy not only can be regarded as a highly atom-economic approach for C3-allylindoles, but also will greatly enrich the chemistry of vinylcyclopropanes.
中文翻译：
通过铱催化的乙烯基环丙烷的支链选择开环反应，对吲哚进行C3-烯丙基化
摘要
已经建立了乙烯基环丙烷与吲哚的铱催化的支链选择性开环反应，其通常以良好的至优异的产率（高达95％）提供C 3-烯丙基吲哚。考虑到在整个过程中没有产生废物，并且几乎没有报道乙烯基环丙烷的支链选择开环反应，该策略不仅可以被视为C3-烯丙二烯的高度原子经济的方法，而且将极大地丰富化学反应。乙烯基环丙烷。
已经建立了乙烯基环丙烷与吲哚的铱催化的支链选择性开环反应，其通常以良好的至优异的产率（高达95％）提供C 3-烯丙基吲哚。考虑到在整个过程中没有产生废物，并且几乎没有报道乙烯基环丙烷的支链选择开环反应，该策略不仅可以被视为C3-烯丙二烯的高度原子经济的方法，而且将极大地丰富化学反应。乙烯基环丙烷。
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