Nanoengineered Electroconductive Collagen-Based Cardiac Patch for Infarcted Myocardium Repair,ACS Applied Materials & Interfaces

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Nanoengineered Electroconductive Collagen-Based Cardiac Patch for Infarcted Myocardium Repair
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-12-03 00:00:00 , DOI: 10.1021/acsami.8b18844
Katsuhiro Hosoyama ₁ , Manuel Ahumada _{1,

2} , Christopher D. McTiernan _{1,

2} , Darryl R. Davis _{3,

4} , Fabio Variola ₅ , Marc Ruel _{1,

4} , Wenbin Liang _{4,

6} , Erik J. Suuronen _{1,

4} , Emilio I. Alarcon _{1,

2}

Affiliation

We have prepared and tested in vivo a novel nanoengineered hybrid electroconductive cardiac patch for treating the infarcted myocardium. Of the prepared and tested patches, only those containing spherical nanogold were able to increase connexin-43 expression in neonatal rat cardiomyocytes cultured under electrical stimulation. In vivo data indicated that only nano-gold-containing patches were able to recover cardiac function. Histological analysis also revealed that connexin-43 levels and blood vessel density were increased, while the scar size was reduced for animals that received the nanogold patch. Thus, our study indicates that the incorporation of electroconductive properties into a collagen-based cardiac patch can improve its therapeutic potential for treating myocardial infarction.

中文翻译：

纳米工程导电性胶原基心脏修补剂，用于心肌梗死修复

我们已经在体内制备并测试了用于治疗梗塞心肌的新型纳米工程混合导电心脏贴片。在准备和测试的贴剂中，只有那些含有球形纳米金的贴剂能够在电刺激下培养的新生大鼠心肌细胞中增加连接蛋白43的表达。体内数据表明，只有含纳米金的贴剂才能恢复心脏功能。组织学分析还显示，接受纳米金贴片的动物的连接蛋白43水平和血管密度增加，而疤痕大小减小。因此，我们的研究表明，将导电特性并入基于胶原的心脏贴剂中可以提高其治疗心肌梗塞的治疗潜力。

更新日期：2018-12-03

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