TBK1 and IKKε restrain cell death

TBK1 and IKKε restrain cell death, Published online: 27 November 2018; doi:10.1038/s41556-018-0239-4

RIPK1 plays a key role in several inflammatory and cell death signalling pathways. Understanding its regulation is pivotal for identifying diseases that might therapeutically benefit from RIPK1 inhibition. Recent studies now show that TBK1 and IKKε constitute a cell death checkpoint that restrains RIPK1 activation.

中文翻译：

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TBK1和IKKε抑制细胞死亡

TBK1和IKKε抑制细胞死亡

TBK1和IKKε抑制细胞死亡，在线发布：2018年11月27日; doi：10.1038 / s41556-018-0239-4

RIPK1在几种炎症和细胞死亡信号通路中起关键作用。了解其调节对于鉴定可能会从RIPK1抑制治疗中受益的疾病至关重要。现在的最新研究表明，TBK1和IKKε构成了抑制RIPK1活化的细胞死亡检查点。