Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
IL-34 promotes foam cell formation by enhancing CD36 expression through p38 MAPK pathway.
Scientific Reports ( IF 3.8 ) Pub Date : 2018-11-26 , DOI: 10.1038/s41598-018-35485-2 Qingyan Liu 1 , Jiao Fan 2 , Jing Bai 3 , Liang Peng 4 , Tao Zhang 3 , Lei Deng 3 , Gaokun Wang 3 , Yu Zhao 3 , Jingguo Nong 3 , Minghua Zhang 5 , Yu Wang 3
Scientific Reports ( IF 3.8 ) Pub Date : 2018-11-26 , DOI: 10.1038/s41598-018-35485-2 Qingyan Liu 1 , Jiao Fan 2 , Jing Bai 3 , Liang Peng 4 , Tao Zhang 3 , Lei Deng 3 , Gaokun Wang 3 , Yu Zhao 3 , Jingguo Nong 3 , Minghua Zhang 5 , Yu Wang 3
Affiliation
|
Atherosclerosis is characterized as a chronic inflammatory disease and macrophage-derived foam cells play a central role during the pathologic processes. A newly discovered cytokine interleukin-34 (IL-34) is closely associated with various inflammatory and autoimmune diseases. Expression of IL-34 in obesity, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), lupus nephritis and coronary artery diseases (CAD) are significantly elevated. However, the role of IL-34 in atherosclerosis remains unknown. In our present study, we found that IL-34 treatment markedly increased the uptake of oxLDL, intracellular total and esterified cholesterol content but not cholesterol efflux, subsequently promoted foam cell formation through up-regulating CD36 expression via p38 MAPK signal pathway in bone marrow derived macrophages (BMDMs). Furthermore, treatment with IL-34 significantly elevated the oxLDL-induced up-regulation of pro-inflammatory cytokines. Our results conclude that IL-34 facilitates foam cell formation by increasing CD36-mediated lipid uptake and suggest a potential new risk biomarker for atherosclerosis.
中文翻译：
IL-34通过通过p38 MAPK途径增强CD36的表达来促进泡沫细胞的形成。
动脉粥样硬化的特征是一种慢性炎症，巨噬细胞源性泡沫细胞在病理过程中起着核心作用。新发现的细胞因子白介素34（IL-34）与各种炎症和自身免疫性疾病密切相关。肥胖，炎性肠病（IBD），类风湿性关节炎（RA），狼疮性肾炎和冠状动脉疾病（CAD）中IL-34的表达明显升高。但是，IL-34在动脉粥样硬化中的作用仍然未知。在我们目前的研究中，我们发现IL-34治疗显着增加了oxLDL的摄取，细胞内总和酯化胆固醇的含量，但没有胆固醇外排，随后通过上调p38 MAPK信号途径在骨髓衍生的CD36表达中促进了泡沫细胞的形成。巨噬细胞（BMDM）。此外，IL-34的治疗显着提高了oxLDL诱导的促炎性细胞因子的上调。我们的结果得出结论，IL-34通过增加CD36介导的脂质摄取来促进泡沫细胞形成，并提示动脉粥样硬化的潜在新危险生物标志物。
更新日期：2018-11-27
中文翻译：
IL-34通过通过p38 MAPK途径增强CD36的表达来促进泡沫细胞的形成。
动脉粥样硬化的特征是一种慢性炎症，巨噬细胞源性泡沫细胞在病理过程中起着核心作用。新发现的细胞因子白介素34（IL-34）与各种炎症和自身免疫性疾病密切相关。肥胖，炎性肠病（IBD），类风湿性关节炎（RA），狼疮性肾炎和冠状动脉疾病（CAD）中IL-34的表达明显升高。但是，IL-34在动脉粥样硬化中的作用仍然未知。在我们目前的研究中，我们发现IL-34治疗显着增加了oxLDL的摄取，细胞内总和酯化胆固醇的含量，但没有胆固醇外排，随后通过上调p38 MAPK信号途径在骨髓衍生的CD36表达中促进了泡沫细胞的形成。巨噬细胞（BMDM）。此外，IL-34的治疗显着提高了oxLDL诱导的促炎性细胞因子的上调。我们的结果得出结论，IL-34通过增加CD36介导的脂质摄取来促进泡沫细胞形成，并提示动脉粥样硬化的潜在新危险生物标志物。
京公网安备 11010802027423号