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The Itch-Scratch Cycle: A Neuroimmune Perspective.
Trends in Immunology ( IF 13.1 ) Pub Date : 2018-11-21 , DOI: 10.1016/j.it.2018.10.001
Madison R Mack 1 , Brian S Kim 2
Affiliation  

Relentless, repetitive itching and scratching is a debilitating feature of many chronic inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch-scratch cycle has historically lacked in-depth mechanistic understanding. However, recent advances at the interface of itch neurobiology and skin immunology have shed new light on this phenomenon. In this review, we highlight recent advances in our understanding of the neuroimmunology of chronic itch centered around three key points of entry into the itch-scratch cycle: the epithelial barrier, the immune system, and the peripheral nervous system. Furthermore, we explore novel neuro-epithelial-immune interactions that may represent promising therapeutic paradigms.

中文翻译:

瘙痒-抓痕循环:神经免疫的观点。

无情、重复的瘙痒和搔抓是许多慢性炎症性皮肤病(如特应性皮炎)的衰弱特征。虽然在临床上广为人知,但这种搔痒循环在历史上一直缺乏深入的机制理解。然而,瘙痒神经生物学和皮肤免疫学的最新进展为这一现象提供了新的启示。在这篇综述中,我们重点介绍了我们对慢性瘙痒神经免疫学理解的最新进展,主要围绕进入瘙痒-搔抓循环的三个关键点:上皮屏障、免疫系统和周围神经系统。此外,我们探索了新的神经-上皮-免疫相互作用,这些相互作用可能代表了有希望的治疗范例。
更新日期:2018-11-27
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