Preparation, Crystal Structures, and Oral Bioavailability of Two Cocrystals of Emodin with Berberine Chloride,Crystal Growth & Design

当前位置： X-MOL 学术 › Cryst. Growth Des. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Preparation, Crystal Structures, and Oral Bioavailability of Two Cocrystals of Emodin with Berberine Chloride
Crystal Growth & Design ( IF 3.2 ) Pub Date : 2018-11-26 00:00:00 , DOI: 10.1021/acs.cgd.8b01257
Yanping Deng ₁ , Yanjie Zhang ₂ , Yali Huang ₂ , Mei Zhang ₂ , Benyong Lou ₂

Affiliation

Two cocrystals of emodin (EM) with berberine chloride (BER), EM-BER (1) and 2EM-BER-EtOH (2), were prepared and characterized. There exist reliable O-H···Cl^– hydrogen-bonding interactions between the 2-hydroxyl group of emodin and chloride anion. Various π–π interactions dominate the packing structures of 1 and 2. In 1, emodin molecules stack into a supramolecular layer through π–π interactions while π–π interactions between berberine cations also result in a similar layer. In 2, berberine cation simultaneously interacts with two different emodin through π–π interactions to give rise to a 1D chainlike array. Cocrystals 1 and 2 present a low moisture adsorption curve in the range of 0–95% relative humidity values at 25 °C. The sustained release of berberine chloride in pure water could be achieved after forming cocrystals 1 and 2. Emodin in the form of cocrystals 1 and 2 has a higher C_max and AUC compared with pure emodin.

中文翻译：

大黄素与氯化小Ber碱的两个共晶体的制备，晶体结构和口服生物利用度

制备并表征了大黄素（EM）与小碱氯化物（BER）的两个共晶体EM-BER（1）和2EM-BER-EtOH（2）。大黄素的2-羟基与氯离子之间存在可靠的OH···Cl ^–氢键相互作用。各种π-π相互作用主导1和2的堆积结构。在图1中，大黄素分子通过π–π相互作用堆积成超分子层，而小ber碱阳离子之间的π–π相互作用也产生了类似的层。在2中，小ber碱阳离子同时通过π-π相互作用与两种不同的大黄素相互作用，从而产生一维链状阵列。共晶1和图2显示了在25°C时相对湿度值在0–95％范围内的低水分吸附曲线。形成共晶1和2后，可以实现在纯水中持续释放小碱氯化物。与纯大黄素相比，共晶1和2形式的大黄素具有更高的C _max和AUC。

更新日期：2018-11-26

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南