Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene†,Food & Function

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Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene†
Food & Function ( IF 5.1 ) Pub Date : 2018-11-23 00:00:00 , DOI: 10.1039/c8fo01971a
Rina Terao _{1,

2,

3,

4} , Akira Murata _{1,

2,

3,

4} , Kazuhiro Sugamoto _{2,

3,

4,

5} , Tomoko Watanabe _{3,

4,

6} , Kiyoko Nagahama _{2,

3,

4,

5} , Keiko Nakahara _{2,

3,

4,

7,

8} , Tomomi Kondo _{3,

4,

6} , Noboru Murakami _{2,

3,

4,

7,

8} , Keiichi Fukui _{3,

4,

6} , Hidemi Hattori _{1,

2,

3,

4,

5} , Nozomu Eto _{1,

2,

3,

4,

5}

Affiliation

Natural killer (NK) cells play an important role in the innate immune system by eliminating cancer cells and virally infected cells. Aging and stress attenuate the activity of NK cells, thereby increasing the risk of various diseases. In this study, we demonstrated that the consumption of a small number of kumquats in an in vivo model could suppress elevated plasma corticosterone levels and reverse the decline in splenocyte cytotoxicity caused by restraint stress. Our results identified β-cryptoxanthin (BCX) as an active kumquat component with a NK cell-activating effect, and R-limonene as an active component that mediates not only the anti-stress effect but also NK cell activation by oral administration. In addition, BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-γ production in KHYG-1 cells, a human NK cell line. Collectively, our findings suggest that the ingestion of a few kumquats on a daily basis can help to combat stress and enhance NK cell activity.

中文翻译：

金桔（Fortunella crassifolia）及其成分β-隐黄质和R-柠檬烯的免疫刺激作用†

天然杀伤（NK）细胞通过消除癌细胞和病毒感染的细胞在先天免疫系统中发挥重要作用。衰老和压力会削弱NK细胞的活性，从而增加各种疾病的风险。在这项研究中，我们证明了在体内模型中食用少量金橘可以抑制血浆皮质酮水平升高，并逆转由约束性压力引起的脾细胞毒性的下降。我们的结果确定了β-隐黄质（BCX）是具有NK细胞激活作用的活性金橘成分，而R-柠檬烯是不仅通过口服给药介导抗应激作用而且还可以激活NK细胞激活的活性成分。此外，BCX，R-柠檬烯和R-柠檬烯代谢物被发现可以增强人NK细胞KHYG-1细胞中的IFN-γ产生。总的来说，我们的研究结果表明，每天摄入一些金橘可以帮助抵抗压力并增强NK细胞的活性。

更新日期：2018-11-23

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