肽-寡核苷酸共轭物的新兴应用：生物活性支架，自组装系统和杂化纳米材料,Organic & Biomolecular Chemistry

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肽-寡核苷酸共轭物的新兴应用：生物活性支架，自组装系统和杂化纳米材料
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-11-22 , DOI: 10.1039/c8ob02436g
Tara MacCulloch _{1,

2,

3,

4,

5} , Alex Buchberger _{1,

2,

3,

4,

5} , Nicholas Stephanopoulos _{1,

2,

3,

4,

5}

Affiliation

肽-寡核苷酸共轭物（POC）是将分子（如DNA）连接到合成肽序列的共价构建体。这些材料将寡核苷酸的可编程自组装与多肽的生物活性和化学多样性融合在一起。近年来，由于每种分子类型的相对优势，POC在许多领域得到了广泛的应用。在这篇综述中，我们将概述POC的合成和应用，重点放在这些分子将产生独特影响的新兴领域。我们首先讨论从合成单体（如亚磷酰胺和功能化氨基酸）合成POC的两种主要策略。然后，我们描述了POC中的四个关键研究领域：（1）用于与细胞接口和控制细胞行为的生物材料；（2）平衡肽和寡核苷酸分子间力的混合自组装系统；（3）模板增强的POC偶联成更大的分子；（4）在自组装的寡核苷酸支架上展示肽。我们还重点介绍了在这四个方向中的每一个上未来应用的几个有希望的领域，并预计POC在跨学科研究中的使用将越来越多。

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Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences. These materials merge the programmable self-assembly of oligonucleotides with the bioactivity and chemical diversity of polypeptides. Recent years have seen the widespread use of POCs in a range of fields, driven the by relative advantages of each molecular type. In this review, we will present an overview of the synthesis and application of POCs, with an emphasis on emerging areas where these molecules will have a unique impact. We first discuss two main strategies for synthesizing POCs from synthetic monomers such as phosphoramidites and functionalized amino acids. We then describe four key fields of research in POCs: (1) biomaterials for interfacing with, and controlling the behavior of cells; (2) hybrid self-assembling systems that balance peptide and oligonucleotide intermolecular forces; (3) template-enhanced coupling of POCs into larger molecules; and (4) display of peptides on self-assembled oligonucleotide scaffolds. We also highlight several promising areas for future applications in each of these four directions, and anticipate ever increasing uses of POCs in interdisciplinary research.

更新日期：2019-02-14

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