Mitochondria as central regulators of neural stem cell fate and cognitive function.,Nature Reviews Neuroscience

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Mitochondria as central regulators of neural stem cell fate and cognitive function.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-01-01 , DOI: 10.1038/s41583-018-0091-3
Mireille Khacho ₁ , Richard Harris ₂ , Ruth S Slack ₂

Affiliation

Emerging evidence now indicates that mitochondria are central regulators of neural stem cell (NSC) fate decisions and are crucial for both neurodevelopment and adult neurogenesis, which in turn contribute to cognitive processes in the mature brain. Inherited mutations and accumulated damage to mitochondria over the course of ageing serve as key factors underlying cognitive defects in neurodevelopmental disorders and neurodegenerative diseases, respectively. In this Review, we explore the recent findings that implicate mitochondria as crucial regulators of NSC function and cognition. In this respect, mitochondria may serve as targets for stem-cell-based therapies and interventions for cognitive defects.

中文翻译：

线粒体作为神经干细胞命运和认知功能的中央调节器。

现在，越来越多的证据表明，线粒体是神经干细胞（NSC）命运决定的中央调节器，对于神经发育和成年神经发生均至关重要，而神经形成和成年神经发生又有助于成熟大脑的认知过程。在衰老过程中，线粒体的遗传突变和累积损伤分别是导致神经发育障碍和神经退行性疾病认知缺陷的关键因素。在这篇综述中，我们探索了将线粒体作为NSC功能和认知的关键调节因子的最新发现。在这方面，线粒体可以作为基于干细胞的疗法和认知缺陷干预的靶标。

更新日期：2019-01-26

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