Abstract

Blue-light-mediated cyclopropanation of indoles with aryl(diazo)acetates has been developed. The salient features of this strategy are that it is metal-free, operationally simple and atom-efficient, and that it uses an environmentally friendly energy source. In this protocol, blue light was employed as the sole energy source for the transformation. A variety of cyclopropane-fused indoline compounds was obtained in moderate to excellent yields and high diastereoselectivities under mild conditions.

Blue-light-mediated cyclopropanation of indoles with aryl(diazo)acetates has been developed. The salient features of this strategy are that it is metal-free, operationally simple and atom-efficient, and that it uses an environmentally friendly energy source. In this protocol, blue light was employed as the sole energy source for the transformation. A variety of cyclopropane-fused indoline compounds was obtained in moderate to excellent yields and high diastereoselectivities under mild conditions.

中文翻译：

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芳基（重氮）乙酸盐在无金属的蓝光介导的吲哚环丙烷化反应中的作用

摘要

已经开发了具有芳基（重氮）乙酸酯的蓝光介导的吲哚环丙烷化反应。该策略的显着特点是无金属，操作简单且原子效率高，并且使用了环保能源。在该协议中，蓝光被用作转化的唯一能源。在温和条件下，以中等至优异的收率和较高的非对映选择性获得了各种环丙烷稠合的二氢吲哚化合物。

已经开发了具有芳基（重氮）乙酸酯的蓝光介导的吲哚环丙烷化反应。该策略的显着特点是无金属，操作简单且原子效率高，并且使用了环保能源。在该协议中，蓝光被用作转化的唯一能源。在温和条件下，以中等至优异的收率和较高的非对映选择性获得了各种环丙烷稠合的二氢吲哚化合物。