Gold Nanoparticles in Cancer Treatment,Molecular Pharmaceutics

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Gold Nanoparticles in Cancer Treatment
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2018-11-19 00:00:00 , DOI: 10.1021/acs.molpharmaceut.8b00810
Krzysztof Sztandera ₁ , Michał Gorzkiewicz ₁ , Barbara Klajnert-Maculewicz _{1,

2}

Affiliation

Colloidal gold has been studied for its potential application in medicine for centuries. However, synthesis and evaluation of various gold nanoparticles have only recently been met with a wide interest of scientists. Current studies confirm numerous advantages of nanogold over different nanomaterials, primarily due to highly optimized protocols for the production of gold nanoparticles of countless sizes and shapes, featured with unique properties. The possibility to modify the surface of nanogold particles with different targeting and functional compounds significantly broadens the range of their potential biomedical applications, with particular emphasis on cancer treatment. Functionalized gold nanoparticles exhibit good biocompatibility and controllable biodistribution patterns, which make them particularly fine candidates for the basis of innovative therapies. Considering the high amount of scientific data on nanogold, this review summarizes recent advances in the field of medical application of gold nanoparticles for the therapy of cancer.

中文翻译：

金纳米粒子在癌症治疗中

胶体金在医学中的潜在应用已有数百年的历史。然而，各种金纳米颗粒的合成和评估直到最近才引起科学家的广泛兴趣。当前的研究证实了纳米金相对于不同纳米材料的众多优势，这主要归因于高度优化的生产无数大小和形状的金纳米颗粒的协议，具有独特的性能。用不同的靶向和功能化合物修饰纳米金颗粒表面的可能性极大地拓宽了其潜在生物医学应用的范围，尤其着重于癌症治疗。功能化的金纳米粒子表现出良好的生物相容性和可控的生物分布模式，这使它们成为创新疗法基础上的优秀候选者。考虑到有关纳米金的大量科学数据，本综述总结了金纳米颗粒在癌症治疗中医学应用领域的最新进展。

更新日期：2018-11-19

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