The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery,Bioconjugate Chemistry

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The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-11-19 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00732
Samuel A. Smith ₁ , Laura I. Selby ₂ , Angus P. R. Johnston ₂ , Georgina K. Such ₁

Affiliation

Many emerging therapies rely on the delivery of biological cargo into the cytosol. Nanoparticle delivery systems hold great potential to deliver these therapeutics but are hindered by entrapment and subsequent degradation in acidic compartments of the endo/lysosomal pathway. Engineering polymeric delivery systems that are able to escape the endosome has significant potential to address this issue. However, the development of safe and effective delivery systems that can reliably deliver cargo to the cytosol is still a challenge. Greater understanding of the properties that govern endosomal escape and how it can be quantified is important for the development of more efficient nanoparticle delivery systems. This Topical Review highlights the current understanding of the mechanisms by which nanoparticles escape the endosome, and the emerging techniques to improve the quantification of endosomal escape.

中文翻译：

纳米粒子的内体逸出：朝着更有效的细胞传递

许多新兴疗法依赖于将生物货物输送到细胞质中。纳米颗粒递送系统具有递送这些治疗剂的巨大潜力，但是由于内在/溶酶体途径的酸性区室中的截留和随后的降解而受到阻碍。能够逃脱内体的工程聚合物输送系统具有解决这一问题的巨大潜力。然而，开发能够将货物可靠地输送到胞质溶胶的安全有效的输送系统仍然是一个挑战。对控制内体逃逸的特性以及如何对其进行量化的深入了解对于开发更有效的纳米颗粒递送系统非常重要。本主题评论重点介绍了当前对纳米粒子逃逸内体的机理的了解，

更新日期：2018-11-19

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