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Design, Synthesis and Anticancer Evaluation of Spiro [cyclohexane‐1,1′‐indene]‐2,5‐diene Analogues
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-11-19 , DOI: 10.1002/slct.201802675 Sivarami Reddy Gangireddy Venkata 1, 2 , Umesh C. Narkhede 1 , Vinod. D Jadhav 1 , Naidu Gangu 2 , Yamini Bobde 3 , Balaram Ghosh 3
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-11-19 , DOI: 10.1002/slct.201802675 Sivarami Reddy Gangireddy Venkata 1, 2 , Umesh C. Narkhede 1 , Vinod. D Jadhav 1 , Naidu Gangu 2 , Yamini Bobde 3 , Balaram Ghosh 3
Affiliation
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A series of spirocyclohexaneindene‐2,5‐diene derivatives were synthesized from Spiro‐Acid 5 which in turn was prepared from the easily accessible starting materials. The structure of spiro‐ester 4 was thoroughly further confirmed by 2D NMR analysis. The synthesized compounds were screened for anticancer activity using murine melanoma cell line (B16F10), human breast cancer cell line (MCF‐7) and human non‐small cell lung carcinoma cell lines (A549). Among them 7 f (tri fluorobenzene) and 7 g (di fluorobenzene) analogues were the most active compounds in all three cell lines in the series.
中文翻译：
螺[环己烷-1,1'-茚] -2-5-二烯类似物的设计，合成和抗癌评估
从Spiro-Acid 5合成了一系列螺环己烷二烯-2-5-二烯衍生物，而后者又是由易于获得的原料制得的。2D NMR分析进一步证实了螺酯4的结构。使用鼠类黑色素瘤细胞系（B16F10），人乳腺癌细胞系（MCF-7）和人非小细胞肺癌细胞系（A549）筛选了合成的化合物的抗癌活性。其中7 f（三氟苯）和7 g（二氟苯）类似物是该系列所有三个细胞系中活性最高的化合物。
更新日期：2018-11-19
中文翻译：
螺[环己烷-1,1'-茚] -2-5-二烯类似物的设计，合成和抗癌评估
从Spiro-Acid 5合成了一系列螺环己烷二烯-2-5-二烯衍生物，而后者又是由易于获得的原料制得的。2D NMR分析进一步证实了螺酯4的结构。使用鼠类黑色素瘤细胞系（B16F10），人乳腺癌细胞系（MCF-7）和人非小细胞肺癌细胞系（A549）筛选了合成的化合物的抗癌活性。其中7 f（三氟苯）和7 g（二氟苯）类似物是该系列所有三个细胞系中活性最高的化合物。
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