A solvent-free catalytic protocol for the Achmatowicz rearrangement,Green Chemistry

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A solvent-free catalytic protocol for the Achmatowicz rearrangement
Green Chemistry ( IF 9.3 ) Pub Date : 2018-11-19 , DOI: 10.1039/c8gc03030h
Guodong Zhao _{1,

2,

3,

4} , Rongbiao Tong _{1,

2,

3,

4,

5}

Affiliation

Reported here is the development of an environmentally friendly catalytic (KBr/oxone) and solvent-free protocol for the Achmatowicz rearrangement (AchR). Different from all previous methods is that the use of chromatographic alumina (Al₂O₃) allows AchR to proceed smoothly in the absence of any organic solvent and therefore considerably facilitates the subsequent workup and purification with minimal environmental impacts. Importantly, this protocol allows for scaling up (from milligram to gram), recycling of the Al₂O₃, and integrating with other reactions in a one-pot sequential manner.

中文翻译：

Achmatowicz重排的无溶剂催化方案

这里报道的是针对Achmatowicz重排（AchR）的环保型催化（KBr / oxone）和无溶剂方案的开发。与所有以前的方法不同的是，使用色谱氧化铝（Al ₂ O ₃）可使AchR在不存在任何有机溶剂的情况下顺利进行，因此可极大地促进后续的后处理和纯化，并且对环境的影响最小。重要的是，该协议允许按比例放大（从毫克到克），回收Al ₂ O ₃以及与其他反应按一锅顺序方式进行整合。

更新日期：2019-01-02

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