Background

Hypertension is one of the common diseases, which brings heavy burden to human race. Currently, western medication is in absolutely dominant position in the treatment of hypertension, but it maintains for a short time and there are various side effects and drug tolerance. Therefore, Chinese medicine has attracted great attention in the treatment field of hypertension, and angelica is one of the most frequently used herbs.

Objectives

In order to give some inspiration to researches in these fields, this article presents the current research status of angelica and its compound formulas treating hypertension and its complications with evidence mapping.

Methods

Main databases were systematically searched, and researches about angelica or its compound formulas containing angelica treating hypertension or its complications were included. EXCEL 2013 was used to integrate and process the data, and the result is showed intuitively with the bubble diagram.

Results

49 RCTs were included after screening. The articles recruited were published with a rising trend along with time. Of the 49 RCTs, there is the outcome measure of general the efficacy in the result part in 34 RCTs (69.4%), and all the clinical effective rate in the angelica intervention group is significantly higher than the control group. There is the outcome measure of reduction of MAP in the result part in 28 RCTs, and 27 RCTs (96.4%) showed that the angelica intervention group is significantly improved than the control group while 1 (3.6%) showed no significant differences. There is the outcome measure of efficacy of target organ protection in the result part in 26 RCTs, and 25 RCTs (96.2%) showed that there is significant difference between the angelica intervention group and the control group. Of the 49 RCTs, there is the outcome measure of adverse effects in the result part in 17 RCTs. 14 RCTs (82.4%) reported no adverse effects, 2 RCTs (11.8%) reported adverse effects rate as lower than 10%, and 1 RCT (7.1%) reported adverse effects rate as higher than 40%.

Conclusion

Current research with low quality has revealed that angelica is effective in reduction of MAP and target organ protection and the adverse effects rate is low, and the effectiveness and safety of angelica needs to be proved by further researches with high quality. Researches of high quality are needed to provide scientific evidence for angelica in treating hypertension and its complications.

中文翻译：

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当归及其复方制剂对高血压及其并发症的治疗作用：证据图谱

背景

高血压是常见疾病之一，给人类带来沉重负担。目前，西药在高血压的治疗中绝对占主导地位，但维持时间很短，并且有各种副作用和药物耐受性。因此，中药在高血压的治疗领域引起了极大的关注，当归是最常用的草药之一。

目标

为了给这些领域的研究以启发，本文通过证据图谱介绍当归及其复方制剂治疗高血压及其并发症的研究现状。

方法

系统地检索了主要数据库，并包括了当归或其含当归治疗高血压或其并发症的复方制剂的研究。使用EXCEL 2013集成和处理数据，并通过气泡图直观地显示结果。

结果

筛选后纳入49个RCT。所招募的文章随着时间的流逝呈上升趋势。在49项RCT中，有34项RCT对结果部分有总体疗效的结果指标（69.4％），当归干预组的所有临床有效率均显着高于对照组。有28项RCT中结果部分MAP降低的结果指标，其中27项RCT（96.4％）显示当归干预组明显优于对照组，而1项（3.6％）则无显着差异。结果部分中有靶器官保护功效的结果指标，其中26个RCT中有25个RCT（96.2％）表明当归干预组与对照组之间存在显着差异。在49个RCT中，在17个RCT中，结果部分有不良反应的结果度量。14个RCT（82.4％）未报告不良反应，2个RCT（11.8％）报告的不良反应率低于10％，1个RCT（7.1％）的不良反应率高于40％。

结论

当前低质量的研究表明，当归可有效降低MAP和保护靶器官，且不良反应率低，当归的有效性和安全性需要进一步的高质量研究来证明。需要进行高质量的研究以为当归治疗高血压及其并发症提供科学依据。