Bandgap Engineered Polypyrrole–Polydopamine Hybrid with Intrinsic Raman and Photoacoustic Imaging Contrasts,Nano Letters

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Bandgap Engineered Polypyrrole–Polydopamine Hybrid with Intrinsic Raman and Photoacoustic Imaging Contrasts
Nano Letters ( IF 9.6 ) Pub Date : 2018-11-16 00:00:00 , DOI: 10.1021/acs.nanolett.8b02901
Qinrui Lin , Yuhong Yang , Yanyun Ma , Ren Zhang , Jiucun Wang , Xin Chen , Zhengzhong Shao ₁

Affiliation

Intrinsically multimodal nanomaterials have revealed their great potential as a new class of contrast agents. We herein report a bandgap engineering strategy to develop an intrinsically Raman-photoacoustic (PA) active probe that is based on semiconducting conjugated polymers. This dual modal probe is prepared by doping a semiconducting conjugated polymer with polydopamine (PDA) through a one-pot reaction. When applied in the polypyrrole (PPy), this strategy can enhance Raman scattering and the PA amplitude of PPy–PDA hybrid by 3.2 and 2.4 times, respectively, so that both signals can be further applied in bioimaging. In the hybrid, such a dual-enhancement effect is achieved by infusing these two macromolecules at the nanoscale to reduce the optical bandgap energy. This work not only introduces a dual modal contrast agent but also provides a new method of manipulating semiconducting polymer’s inherent optical features for bioimaging.

中文翻译：

带隙工程聚吡咯-聚多巴胺杂化物与本征拉曼光谱和光声成像对比

本质上，多峰纳米材料已经显示出其作为新型造影剂的巨大潜力。我们在此报告了一种带隙工程策略，以开发基于半导体共轭聚合物的固有拉曼光声（PA）有源探针。通过单锅反应将半导体共轭聚合物与聚多巴胺（PDA）掺合来制备这种双模式探针。当应用于聚吡咯（PPy）时，该策略可以分别将拉曼散射和PPy-PDA杂化体的PA振幅提高3.2倍和2.4倍，因此这两种信号都可以进一步应用于生物成像。在杂化物中，通过在纳米级注入这两个大分子以减小光学带隙能量来实现这种双重增强效果。

更新日期：2018-11-16

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